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KE Dipeptide | Thymus Immune Bioregulator
Vilon is a Khavinson bioregulator dipeptide (KE) consisting of lysine and glutamic acid, originally isolated from thymus gland extracts. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it acts as a molecular signaling compound that restores normal gene expression and protein synthesis in immune and epithelial cells. Research shows Vilon increases mean lifespan by 20-40% in animal studies and suppresses tumor development.
Vilon works through epigenetic modulation, restoring chromatin structure and gene expression in immune cells. It stimulates thymocyte proliferation, activates T-helper cells, and increases the proliferative index in thymus tissue (from 26% to 37% in studies). The peptide modulates tyrosine phosphorylation of mitogen-activated cytoplasmic kinases and helps rejuvenate aged immune systems by restoring proper gene expression patterns.
KE
Lysine
Position 1
Glutamic Acid
Position 2
Stimulates thymocyte proliferation and enlarges thymic lobules.
Activates T-helper cells and improves immune response.
Restores chromatin structure and gene expression in aged lymphocytes.
Long-term treatment increased mean lifespan 20-40% in rodent studies.
Suppresses development of spontaneous and induced tumors.
Promotes recovery in tissues exposed to radiation damage.
Restores brush border membrane enzyme levels in aged animals.
Enhances intestinal barrier function in aged rats.
Available in capsule form for oral administration. As the shortest Khavinson peptide (just 2 amino acids), Vilon is easily absorbed orally. Typical protocol involves 10-20 day cycles, repeated 2-3 times per year.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable form available for direct administration.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Both target thymus/immune system; complementary mechanisms.
Often combined in comprehensive anti-aging Khavinson protocols.
Both have immunoprotecting properties; different mechanisms.
Related immune peptides; can be used in comprehensive protocols.
Immune activation and gene expression modulation begins
Effects persist due to epigenetic changes
Immune function improvements
Cumulative benefits; longevity effects in animal models
Biogerontology
Long-term treatment with peptide preparations including Vilon increased mean lifespan 20-40% and suppressed tumorigenesis.
Bulletin of Experimental Biology and Medicine
Vilon improved lymphocytes from old people by restoring chromatin structure and gene expression.
PMC
Vilon and other Khavinson peptides modulate key proliferative patterns and tyrosine phosphorylation of kinases.
Advances in Gerontology
Vilon and related peptides possess age-associated immunoprotecting properties in the spleen.
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