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KED | Vascular Bioregulator Peptide
Vesugen is a Khavinson bioregulator tripeptide developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology. Composed of three amino acids (lysine, glutamic acid, aspartic acid), it targets the vascular system and protects blood vessels from age-related decline. Research shows it limits atherosclerosis development, decreases endothelial dysfunction, and activates stem cells. Like other short Khavinson peptides, Vesugen penetrates to the nucleus where it influences gene expression.
Vesugen works through epigenetic regulation by interacting with DNA promoter regions, particularly affecting Ki-67 gene expression which controls cell division. It plays a prominent role in regulating sirtuin 1 (SIRT1) protein levels - a key anti-aging protein activated during calorie restriction. Vesugen enhances mesenchymal stem cell proliferation, reduces senescence markers, improves cell differentiation, and may reverse the Senescence-Associated Secretory Phenotype (SASP) implicated in age-related cardiovascular disease.
KED
Lysine
Position 1
Glutamic Acid
Position 2
Aspartic Acid
Position 3
Protects blood vessels from age-related deterioration through gene expression regulation.
Limits development of atherosclerotic plaques in blood vessels.
Decreases endothelial dysfunction that contributes to cardiovascular disease.
Regulates sirtuin 1 levels, mimicking some benefits of calorie restriction.
Enhances mesenchymal stem cell proliferation and reduces senescence.
Reverses senescence-associated secretory phenotype in aging cells.
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable form available for direct administration, bypassing GI tract.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Complementary cardiovascular bioregulators - Vesugen for vessels, Cardiogen for heart tissue.
Often combined in comprehensive anti-aging Khavinson protocols.
Different organ targets; can be used in comprehensive bioregulator protocols.
Part of Khavinson bioregulator family; targets different tissue.
Gene expression modulation and SIRT1 activation begins
Effects persist due to epigenetic changes
Vascular function improvements
Cumulative benefits with periodic cycles
Advances in Gerontology
Comprehensive review of bioregulator peptides including Vesugen and their epigenetic mechanisms.
Bulletin of Experimental Biology and Medicine
Short peptides regulate sirtuin 1 levels and protect vascular tissue from aging.
Cell Technologies in Biology and Medicine
Vesugen enhances MSC proliferation and reduces senescence markers in stem cells.
Plain-English guides and study summaries from published literature.
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