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Compare 2 prices for SNAP-8. Cheapest: R750.00. Average: R750.00.
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SA Peptides
Best
SNAP-8 |
R750.00 | R37.50/mg | In Stock | R140.00 |
Lab Tested
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SNAP-8 20mg |
R750.00 | R37.50/mg | In Stock | R250.00 |
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Acetyl Octapeptide-3 | Anti-Wrinkle & Expression Line Peptide
Synthetic octapeptide functioning as topical Botox alternative, targeting dynamic facial wrinkles through SNARE complex modulation. Up to 63% wrinkle depth reduction demonstrated clinically.
Mimics SNAP-25 protein N-terminal, competitively inhibits SNARE complex formation, reduces acetylcholine release at neuromuscular junctions.
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Ac
Position 1
Glutamic Acid
Position 2
Glutamic Acid
Position 3
Methionine
Position 4
Glutamine
Position 5
Arginine
Position 6
Arginine
Position 7
Alanine
Position 8
Aspartic Acid
Position 9
NH2
Position 10
Demonstrates up to 63% reduction in wrinkle depth around eyes/forehead over 28 days.
Targets horizontal lines from repetitive eyebrow-raising and facial expressions.
Reduces periorbital wrinkles via localized muscle relaxation without affecting natural expressions.
43% inhibition efficiency at therapeutic concentrations.
Localized relaxation at application sites without systemic effects.
Slows new expression line formation before becoming static wrinkles.
Most studied and clinically validated route; applied directly to skin for localized effects.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Anti-Aging | 3-5% concentration | 2x daily | Serum/cream |
| Intensive Wrinkle Treatment | 5-10% concentration | 2x daily | Targeted application |
| Eye Area Treatment | 3-5% concentration | 2x daily | Eye cream/serum |
| Preventive Use | 3% concentration | 1-2x daily | Daily moisturizer |
Research-only subcutaneous administration; direct tissue delivery with limited clinical data.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Initial Phase (Weeks 1-4) | 0.33mg (330mcg) | 1x daily | SubQ |
| Mid-Phase (Weeks 5-8) | 0.5mg (500mcg) | 1x daily | SubQ |
| Target Phase (Weeks 9-12) | 1.0mg (1000mcg) | 1x daily | SubQ |
Parent compound with same mechanism; SNAP-8 ~30% more potent; may be redundant when combined.
Research shows 47% total inhibition combined vs 38% and 7% independently.
Complementary mechanisms—SNAP-8 reduces expression lines; GHK-Cu promotes collagen synthesis.
Excellent combination; hydration and plumping effects enhance wrinkle reduction.
Safe together; niacinamide calms barrier while SNAP-8 targets expression lines.
Both potent actives; introduce slowly or use separately (SNAP-8 morning, retinol evening).
pH differences may affect stability; use Vitamin C morning, SNAP-8 evening.
Acids destabilize peptides; use at different times—acids morning, peptides evening.
Complementary anti-aging—Matrixyl stimulates collagen; SNAP-8 relaxes muscles.
Skin feels slightly smoother; minimal visible changes as peptide accumulates
Initial fine line reduction, especially with expressions; skin appears more relaxed
Significant wrinkle depth reduction (~35% average); expression lines less pronounced
Maximum efficacy (~63% reduction); forehead and eye area show notable improvement
Maintained results with continued use; effects diminish over 2-4 weeks if discontinued
First multicenter RCT of parent compound; 48.9% anti-wrinkle efficiency vs 0% placebo (P<0.01).
Argireline reduced wrinkle depth up to 30% in 30 days; established SNARE complex destabilization mechanism.
SNAP-8 showed 43% SNARE complex inhibition; synergistic with Leuphasyl (47% total vs 38% and 7% independently).
Microneedle patches enhanced SNAP-8 delivery and wrinkle reduction vs topical alone.
Plain-English guides and study summaries from published literature.
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