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Compare 4 prices for Mots-C. Cheapest: R380.00. Average: R449.75.
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Helix Collective
Best
Mots-C 5mg |
R380.00 | R76.00/mg | In Stock | R170.00 |
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Mots-C 5mg |
R459.00 | R91.80/mg | In Stock | R250.00 |
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Mots-C 5mg |
R460.00 | R92.00/mg | In Stock | R170.00 |
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Mots-C 5mg |
R500.00 | R100.00/mg | In Stock | Free over R2,000 |
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Mitochondrial-Derived Peptide | Metabolic Regulator
MOTS-c is a mitochondrial-derived peptide that operates as a mitohormone through the Folate-AICAR-AMPK pathway. Under metabolic stress, it translocates to the nucleus to bind stress-response transcription factors (NRF2, ATF1/ATF7), regulating genes involved in metabolism and cellular adaptation.
Inhibits the folate cycle leading to AMPK activation. Under metabolic stress, translocates to nucleus to bind stress-response transcription factors, regulating genes involved in metabolism, insulin sensitivity, and cellular adaptation.
MRWQEMGYIFYPRKLR
Methionine
Position 1
Arginine
Position 2
Tryptophan
Position 3
Glutamine
Position 4
Glutamic Acid
Position 5
Methionine
Position 6
Glycine
Position 7
Tyrosine
Position 8
Isoleucine
Position 9
Phenylalanine
Position 10
Tyrosine
Position 11
Proline
Position 12
Arginine
Position 13
Lysine
Position 14
Leucine
Position 15
Arginine
Position 16
Improves insulin sensitivity by ~30% in animal studies through AMPK activation.
Restores metabolic function via insulin receptor sensitization.
Promotes fatty acid oxidation despite identical caloric intake.
Reverses age-dependent physical decline in animal models.
Enhances mitochondrial function via PGC-1α activation.
6.4% median lifespan extension observed in mice studies.
12-15% improvement in running performance from single dose in studies.
Exercise induced 11.9-fold increase in skeletal muscle MOTS-c.
Supports muscle recovery and adaptation to exercise.
Subcutaneous injection is the primary route. Optimal administration is morning before exercise. AMPK activation occurs within 30 minutes.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Metabolic health | 5-10mg | Once daily | SubQ |
| Anti-aging protocol | 15mg | 3x weekly | SubQ |
| Exercise performance | 10-15mg | Pre-workout | SubQ |
| Conservative start | 5mg | Once daily | SubQ |
Both activate AMPK; monitor for additive hypoglycemic effects.
Complementary mitochondrial enhancement through different pathways.
Different mechanisms allow safe combination.
Both are AMPK activators; monitor for additive effects.
Complementary SIRT1/AMPK activation pathways.
May require dose adjustments to prevent hypoglycemia.
AMPK pathway activation; initial glucose tolerance improvements
Enhanced exercise capacity; improved insulin sensitivity
Sustained metabolic benefits; potential body composition changes
Maximum mitochondrial function enhancement; metabolic flexibility
Ophthalmology Research
Dose-dependent protective effects on retinal cells in AMD models.
Cell Metabolism
Prevented obesity, improved insulin sensitivity by ~30% in high-fat diet mice.
Nature Communications
Enhanced physical performance across age groups; exercise induced 11.9-fold increase in skeletal muscle MOTS-c.
Cell Metabolism
Nuclear translocation within 30 minutes under metabolic stress.
Physiological Reports
Single dose improved running time 12%, distance 15%.
Pharmacological Research
Alleviated hyperglycemia in gestational diabetes model.
Plain-English guides and study summaries from published literature.
Guides
8 min
MOTS-c is a mitochondrial-derived peptide studied for metabolic signalling, insulin sensitivity, mitochondrial function and exercise performance. Here is what current research-focused discussion supports, and where caution is needed.
Read article
Guides
8 min
MOTS-c is often discussed in relation to energy, metabolism and mitochondrial signalling. Early fatigue should be interpreted cautiously, not assumed to be proof that it is working.
Read article
Guides
8 min
MOTS-c is a mitochondrial-derived peptide studied for metabolic adaptation, insulin sensitivity, exercise performance and ageing. Here is what the research says, and what it does not yet prove.
Read article
Guides
8 min
MOTS-c is studied for metabolic signalling and mitochondrial function, but that does not mean it should feel like a stimulant. Fatigue reports need careful context.
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