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Kisspeptin Price Comparison

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Best Price R350.00
Average R350.00
Highest R350.00
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Pure Peptides SA logo
Pure Peptides SA

Kisspeptin

In Stock 2mg
R350.00
+ R200.00 delivery

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Kisspeptin Profile

Emerging

KISS1 Gene Product | Reproductive Neuropeptide

Overview

Kisspeptin acts as a master regulator of the reproductive system, stimulating GnRH neurons essential for puberty, fertility, and reproductive function.

Mechanism of Action

Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, triggering pulsatile GnRH release, which stimulates pituitary LH/FSH secretion and gonadal steroid production.

Key Benefits

  • Potent reproductive hormone stimulation (LH/FSH)
  • Restoration of natural testosterone production
  • Fertility enhancement
  • Sexual function support
  • Hypogonadism treatment potential

Quick Stats

Typical Dose
100-200 mcg per injection
Frequency
Single dose for testing, or 2-3 times weekly (NEVER daily - causes desensitization)
Cycle Duration
2-4 weeks
Storage
Lyophilized: Room temperature. Reconstituted: 2-8°C. KP-10: use within 7 days. KP-54: use within 14 days

Molecular Information

Molecular Weight
1,213.42 Da (KP-10) / 6,087 Da (KP-54)
Length
10-54 amino acids
Type
Neuropeptide family (RFamide)
Half-Life
~4 minutes (KP-10), ~28-32 minutes (KP-54)

Amino Acid Sequence

One-letter: ??NWNSFGLRF?
Kis
1

Kisspeptin

Position 1

10:
2

10: Tyr

Position 2

Asn
3

Asparagine

Position 3

Trp
4

Tryptophan

Position 4

Asn
5

Asparagine

Position 5

Ser
6

Serine

Position 6

Phe
7

Phenylalanine

Position 7

Gly
8

Glycine

Position 8

Leu
9

Leucine

Position 9

Arg
10

Arginine

Position 10

Phe
11

Phenylalanine

Position 11

NH2
12

NH2

Position 12

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Modifications

C-terminally amidated peptides from 145 amino acid KISS1 precursor

Research Indications

The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research.

Hypogonadotropic Hypogonadism

Most Effective

Restores reproductive hormone secretion in functional or congenital cases by stimulating dormant GnRH axis.

IVF Ovulation Trigger

Most Effective

Triggers oocyte maturation with 45% live birth rate and zero severe OHSS cases; safer than hCG.

Hypothalamic Amenorrhea

Effective

Restores reproductive hormone pulsatility in women with hypothalamic amenorrhea.

Hypoactive Sexual Desire Disorder (Men)

Effective

Modulates sexual brain processing; increases penile tumescence by 56% vs placebo.

Hypoactive Sexual Desire Disorder (Women)

Effective

Modulates sexual and attraction brain processing; increases self-reported sexiness.

Energy Metabolism

Moderate

Preclinical evidence suggests influence on energy expenditure and activity levels.

Dosing Protocols

injectable

Standard administration route; allows precise dosing and rapid hormone stimulation.

Goal Dose Frequency Route
Gonadotropin stimulation 100-200mcg Single dose or 2-3x weekly SubQ
Fertility support 0.4-1.0 nmol/kg (50-150mcg) As directed by physician SubQ (KP-54)
Sexual function (clinical) 1 nmol/kg/h 75-minute IV infusion IV infusion

Key Tips

  • Rapid LH/FSH stimulation
  • Precise dose control
  • Flexible dosing schedules
Materials Needed
Bacteriostatic water (BAC water) Insulin syringes (0.5-1 mL) Alcohol swabs Sterile work surface
Steps
  1. 1 Clean work area and hands thoroughly with alcohol
  2. 2 Calculate required BAC water volume
  3. 3 Draw calculated water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until dissolved (never shake)
  6. 6 Store in refrigerator at 2-8°C
  7. 7 Use within 7 days for KP-10; 14 days for KP-54

nasal

Emerging non-invasive delivery method; 2025 research demonstrates effectiveness with stable formulations.

Goal Dose Frequency Route
Gonadotropin stimulation (research) 12.8 nmol/kg Single dose Intranasal

Key Tips

  • Non-invasive administration
  • Rapid gonadotropin stimulation
  • Stable 60-day formulation potential

Peptide Interactions

GnRH

Synergistic

Kisspeptin stimulates GnRH release; works upstream in reproductive axis.

HCG

Compatible

Serves as potentially safer alternative for IVF ovulation triggering.

Testosterone

Compatible

Restores natural testosterone production through LH stimulation.

Estrogen

Compatible

Kisspeptin function modulated by sex steroids in feedback loops.

What to Expect

Hours 2-5

LH surge peaks at 3-5x baseline

Hours 12-14

LH returns to baseline

Days 1-2

Testosterone/estradiol increase in response to LH

Weeks 2-4

Potential improvements in sexual function and libido

Side Effects & Safety

Common Side Effects

  • Minimal acute side effects reported
  • Potential mild cardiovascular effects

Monitoring

  • Use sterile injection technique
  • Avoid daily administration (maximum 2-3x/week)
  • Monitor for ovarian hyperstimulation in women
  • Consult reproductive endocrinologist for fertility use

Stop Signs

  • Ovarian hyperstimulation signs: severe pelvic pain, bloating, nausea
  • Chest pain or cardiovascular symptoms
  • Severe headaches or visual disturbances
  • Persistent injection site reactions

Contraindications

  • Not recommended during pregnancy or breastfeeding
  • Caution with cardiovascular disease history
  • Daily dosing causes receptor desensitization

Quality Checklist

Good Signs

  • White, fluffy powder; proper freeze-drying indicated
  • Clear solution after reconstitution; no particles or cloudiness
  • Protected from light in amber/opaque vials

Warning Signs

  • Slight compaction acceptable if dissolves completely with gentle swirling

Bad Signs

  • Discoloration or yellowing indicates oxidation/degradation
  • Cloudy after reconstitution indicates degradation or contamination

Research & References

Key References

  1. 2023

    Kisspeptin for Hypoactive Sexual Desire Disorder in Men

    Modulated sexual brain activity; increased penile tumescence by 56% vs placebo. JAMA Network Open.

  2. 2022

    Kisspeptin for HSDD in Women

    Modulated sexual and attraction processing; increased self-reported sexiness. JAMA Network Open.

  3. 2017

    Kisspeptin as IVF Ovulation Trigger

    45% live birth rate with zero severe OHSS; safer than hCG trigger. Journal of Clinical Investigation.

  4. 2025

    Intranasal Kisspeptin Administration

    Non-invasive delivery with rapid gonadotropin stimulation; stable 60-day formulation. eBioMedicine.

Search PubMed for Kisspeptin

Research Library

Kisspeptin research & guides

Plain-English guides and study summaries from published literature.

View all 2
Kisspeptin in South Africa: Reproductive Hormone Research Guide Guides 8 min

Kisspeptin in South Africa: Reproductive Hormone Research Guide

Kisspeptin is an upstream reproductive neuropeptide studied for GnRH, LH and FSH signalling, with interest in fertility, puberty, sexual function and hormone-axis research.

Read article
Kisspeptin Explained: The Peptide That Helps Control Reproductive Hormones Guides 8 min

Kisspeptin Explained: The Peptide That Helps Control Reproductive Hormones

Kisspeptin is an upstream reproductive neuropeptide studied for its role in GnRH, LH and FSH signalling, fertility research, puberty and sexual-function pathways.

Read article

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