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HCG Price Comparison

Live prices from 6 SA suppliers, from R300.00, compared side by side so you never overpay.

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Best Price R300.00
Average R441.80
Highest R750.00
You Could Save 60%
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Best Price
Save 60%
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Helix Collective

HCG 5,000IU

In Stock 5,000IU
R300.00
+ R170.00 delivery
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Buy Peptides

HCG 5,000IU

R330.00
In Stock 5,000IU
Save 56% + R250.00 delivery
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JP Research

HCG

R349.00
In Stock 5,000IU Lab Tested
Save 53% FREE delivery
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Grow Nova

HCG 5,000IU

R480.00
In Stock 5,000IU
Save 36% + R170.00 delivery
White Rabbit Labs logo
White Rabbit Labs

HCG 5,000IU

R750.00
In Stock 5,000IU
+ R120.00 delivery

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HCG Profile

Fda Approved FDA Approved

Human Chorionic Gonadotropin | LH Receptor Agonist

Overview

HCG is a glycoprotein hormone naturally produced by the placenta during pregnancy that binds LH receptors to stimulate testosterone and estrogen biosynthesis. FDA-approved for cryptorchidism, hypogonadotropic hypogonadism, and ovulation induction.

Mechanism of Action

Binds to LH receptors on Leydig cells in testes, stimulating testosterone production with a half-life of 24-36 hours, peak levels 6-12 hours post-injection, and 40-50% bioavailability via SubQ or IM routes.

Key Benefits

  • Maintains testicular function during TRT
  • Preserves fertility and prevents testicular atrophy
  • Stimulates endogenous testosterone production
  • Induces ovulation in women
  • FDA-approved for multiple indications
  • Well-established safety profile

Quick Stats

Typical Dose
250-1500 IU (lower for TRT adjunct, higher for fertility)
Frequency
2-3 times weekly, or every other day for lower doses
Cycle Duration
Ongoing with TRT or 3-6 months for fertility protocols
Storage
Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 30-60 days

Molecular Information

Molecular Weight
36,700 Da
Length
237 amino acids (alpha: 92, beta: 145)
Type
Heterodimeric glycoprotein
Half-Life
24-36 hours

Modifications

Extensive N-linked and O-linked glycosylation extending half-life

Research Indications

The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research.

TRT Adjunct

Most Effective

Maintains intratesticular testosterone at baseline during testosterone therapy, preventing atrophy and preserving fertility.

Hypogonadotropic Hypogonadism

Most Effective

FDA-approved for secondary hypogonadism; combined with FSH for spermatogenesis induction.

Post-Cycle Therapy

Effective

Restores testicular function after anabolic steroid cycles.

Ovulation Induction

Most Effective

FDA-approved trigger for follicular maturation; 15-25% pregnancy rate per cycle.

Cryptorchidism

Moderate

FDA-approved for prepubertal undescended testes not due to anatomical obstruction; ~25% success rate.

Dosing Protocols

injectable

Subcutaneous or intramuscular injection. Administer 2-3 times weekly, evenly spaced. For TRT, many inject HCG on days between testosterone injections.

Goal Dose Frequency Route
TRT Adjunct (Low) 250-500 IU Every other day SubQ/IM
TRT Adjunct (Standard) 500-1000 IU Twice weekly SubQ/IM
HCG Monotherapy 1500-2000 IU 2-3x weekly IM
Fertility (with FSH) 1500-2000 IU 2-3x weekly IM
Cryptorchidism (Pediatric) 1000-5000 IU 2-3x weekly for 3-4 weeks IM
Ovulation Trigger (Female) 5000-10,000 IU Single dose IM/SubQ
PCT Protocol 1000-1500 IU Every other day for 2-3 weeks SubQ/IM

Key Tips

  • SubQ: Abdominal fat, thigh
  • IM: Deltoid, gluteal (rotate sites)
  • Evenly space doses throughout week
Materials Needed
HCG lyophilized powder vial (typically 5000 or 10,000 IU) Bacteriostatic water or sodium chloride diluent (provided) Insulin syringes (29-31 gauge for SubQ) Alcohol prep pads
Steps
  1. 1 Remove vial and diluent from packaging
  2. 2 Clean rubber stoppers with alcohol swabs
  3. 3 Draw diluent into syringe (typically 1-2mL provided)
  4. 4 Slowly inject diluent into HCG vial, aiming at vial wall
  5. 5 Gently swirl to dissolve - do not shake vigorously
  6. 6 Allow to sit until completely dissolved and clear
  7. 7 Calculate concentration (e.g., 5000 IU in 2mL = 2500 IU/mL)
  8. 8 Label with reconstitution date and concentration
  9. 9 Store reconstituted HCG at 2-8°C
  10. 10 Use within 30-60 days

Peptide Interactions

Testosterone

Synergistic

Commonly combined in TRT to maintain testicular function and preserve fertility.

Clomiphene (Clomid)

Monitor

Use sequentially; both affect HPG axis.

Aromatase Inhibitors

Compatible

Commonly combined; HCG increases intratesticular aromatase activity.

GnRH Analogs

Monitor

Monitor combination effects on gonadotropin axis.

FSH (Follitropin)

Synergistic

Synergistic for fertility; 70-90% spermatogenesis induction rate.

Kisspeptin

Compatible

Complementary mechanisms for HPG axis stimulation.

Thyroid Hormones

Monitor

HCG has weak TSH-like activity; monitor thyroid function.

Metformin

Compatible

Protective combination for metabolic health.

What to Expect

Day 1-3

Cellular-level action begins; no immediate noticeable effects

Week 1-2

Testosterone increase detectable on labs; possible mood/energy improvement

Week 2-4

Testicular fullness/size improvement noticeable; improved well-being

Week 4-8

Stable testosterone levels; fertility parameters beginning to improve

Month 2-3

Sperm count improvements if used for fertility; sustained testicular function

Long-term

Maintained testicular size and function with ongoing use

Side Effects & Safety

Common Side Effects

  • Gynecomastia (breast tenderness/swelling) due to increased estrogen
  • Headaches, irritability, and mood swings (especially initially)
  • Fluid retention and edema
  • Potential antibody formation with long-term use

Monitoring

  • Monitor estrogen levels - may need aromatase inhibitor
  • Regular testosterone and fertility panel
  • Watch for gynecomastia signs

Stop Signs

  • Signs of gynecomastia (breast tenderness, swelling, nipple sensitivity)
  • Severe or persistent headaches
  • Signs of blood clots (leg swelling/pain, shortness of breath, chest pain)
  • Allergic reactions (rash, hives, difficulty breathing, facial swelling)
  • Severe abdominal pain or bloating in women (possible OHSS)
  • Testicular pain or swelling beyond normal
  • Significant mood changes (depression, aggression, severe irritability)
  • Vision changes

Contraindications

  • Hormone-sensitive cancers (prostate, breast)
  • Pregnancy (except as prescribed)
  • Precocious puberty risk in children

Quality Checklist

Good Signs

  • White to off-white lyophilized powder or cake in sealed vial
  • Completely clear solution after reconstitution
  • Proper labeling: Pregnyl, Novarel (urinary), Ovidrel (recombinant)
  • Clear expiration and lot number
  • Cold chain compliance (recombinant requires refrigeration throughout)

Warning Signs

  • Generic/compounding pharmacy products - quality varies
  • Ensure compounding pharmacy is accredited

Bad Signs

  • Cloudiness, discoloration, or floating particles indicates degradation
  • Compromised vial seal or expired product

Research & References

Key References

  1. 2005

    HCG for Intratesticular Testosterone Maintenance

    250 IU HCG every other day during TRT maintains intratesticular testosterone at baseline, preventing atrophy and preserving fertility.

  2. 2013

    HCG Monotherapy for Hypogonadism

    HCG monotherapy (1500-2000 IU twice weekly) effectively increased testosterone and improved symptoms while maintaining fertility.

  3. 2018

    Spermatogenesis Induction with HCG/FSH

    Combined HCG and FSH therapy induces spermatogenesis in 70-90% of men with hypogonadotropic hypogonadism.

  4. 2014

    Cryptorchidism Treatment Meta-Analysis (Cochrane)

    Meta-analysis of 1,231 boys showing ~25% success rate for hormonal treatment of cryptorchidism.

  5. 2017

    Ovulation Induction Success Rates

    HCG trigger achieves pregnancy rates of 15-25% per cycle in clomiphene/letrozole protocols.

Search PubMed for HCG

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