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Copper Peptide | Skin Regeneration & Anti-Aging Compound
Naturally occurring copper tripeptide found in human plasma, saliva, and urine. GHK-Cu affects 31.2% of human genes and declines significantly with age—from ~200 ng/ml at age 20 to ~80 ng/ml at age 60. Known for exceptional skin regeneration, wound healing, and anti-aging properties.
Penetrates skin layers, activates fibroblasts, stimulates collagen and elastin synthesis, promotes angiogenesis, and modulates inflammatory responses. The copper ion is essential for enzyme cofactor activity in tissue repair processes.
GHK
Glycine
Position 1
Histidine
Position 2
Lysine
Position 3
Increases type I and III collagen production by up to 70% in human dermal fibroblasts.
Stimulates elastin synthesis for improved skin elasticity and resilience.
Strengthens protective barrier and improves moisture retention.
Promotes hair follicle enlargement and extends anagen (growth) phase.
Improves scalp circulation and reduces inflammation.
Regulates inflammatory cytokine production.
Protects tissues from oxidative stress and damage.
Most common delivery method for skin and hair applications. Available as creams, serums, and solutions.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Anti-aging skincare | 0.5-1% cream | 1-2x daily | Topical application |
| Hair growth stimulation | 1-2% solution | 1x daily | Scalp massage |
| Wound healing | 1-2% gel | 2-3x daily | Direct application |
| General skin health | 0.5% serum | 1x daily | Face and neck |
| Intensive repair | 2% cream | 1x daily | Targeted areas |
Injectable form provides systemic effects but is not FDA-approved. Requires refrigeration after reconstitution.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Systemic anti-aging | 1-2mg | 1x daily | SubQ |
| Enhanced regeneration | 2-3mg | 1-2x daily | SubQ |
Complementary tissue healing and regeneration pathways.
Enhanced wound healing and tissue repair when combined.
Both affect melanin production; use caution when combining.
Risk of copper toxicity; do not combine with oral copper supplements.
No known interactions.
May affect copper absorption and activity.
Improved skin texture and hydration
Reduction in fine lines and increased skin smoothness
Enhanced skin firmness and elasticity
Visible improvement in skin tone and clarity
6-12 weeks for initial results
Int J Mol Sci
Demonstrates broad regenerative potential across multiple tissue types including skin, hair, and bone.
Biomed Res Int
GHK-Cu increased elastin and collagen production in human dermal fibroblasts by up to 70%.
Oxid Med Cell Longev
Shows neuroprotective and antioxidant effects in aged mice at 10 mg/kg dosing.
Plain-English guides and study summaries from published literature.
GHK-Cu is a copper-binding peptide with a broader skin repair research profile than many cosmetic peptides. Here is how it compares with Matrixyl, Argireline, SNAP-8 and similar ingredients.
Read articleGHK-Cu is best known as a skincare copper peptide, but its research profile extends to collagen, wound healing, tissue remodelling, inflammation and gene expression.
Read articleBe the first to know when prices drop on your favourite peptides
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