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Compare 2 prices for Dihexa. Cheapest: R550.00. Average: R725.00.
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Crono Pharm
Best
Dihexa |
R550.00 | R55.00/mg | In Stock | R150.00 |
Lab Tested
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Dihexa 10mg |
R900.00 | R90.00/mg | In Stock | R250.00 |
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Synaptogenic Peptide | Cognitive Enhancement
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis. It is 10 million times more potent than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
Binds to hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and potentiates its activity at c-Met receptor, activating PI3K/AKT pathways and promoting new synaptic connections with extraordinary potency.
Hexanoyl-Tyr-Ile-Ahx-NH2
Improvements in spatial, working, and consolidation demonstrated across animal models.
Enhanced acquisition through increased synaptic plasticity.
Restoration in impairment models including scopolamine-induced amnesia.
Reduced amyloid burden in Alzheimer's models.
Decreased neuroinflammation and glial activation.
Protection of synapses in neurodegeneration models.
3-fold increase in dendritic spine formation demonstrated.
Increases brain-derived neurotrophic factor expression.
Promotes new blood vessel formation in brain.
Oral capsules/tablets are the most convenient form. Take in the morning with or without food. No reconstitution required.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard cognitive enhancement | 8-10mg | 1x daily (morning) | Oral |
| Low-dose maintenance | 5mg | 1x daily | Oral |
| Intensive learning protocol | 10-15mg | 1x daily | Oral |
Subcutaneous/intraperitoneal injection provides more consistent dosing. Requires refrigerated storage after reconstitution.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Research protocol | 0.5mg/kg daily | Daily or 3x weekly | SubQ/IP |
| Standard injectable | 2-5mg total | 1x daily | SubQ |
Topical cream formulation with limited research data. Experimental route.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Topical application | 10-20mg cream | 1x daily | Inner forearms, shoulders (rotate sites) |
Enhanced cognitive benefits; monitor for overstimulation.
Synergistic effects; watch for neural overstimulation.
Different mechanisms; no negative interactions known.
Both affect neuroplasticity strongly; avoid concurrent use.
Some stack for cognition; limited safety data.
Complementary mechanisms for cellular health.
Both potently neuroactive; may cause overstimulation.
Different targets; no known interactions.
Subtle cognitive shifts; possible headaches during adaptation
Improved focus and memory formation
Peak cognitive benefits and enhanced learning
Effects may persist for days to weeks after discontinuation
Clinical Development
Phosphate pro-drug of Dihexa currently in Phase 2 clinical trials for Alzheimer's and Parkinson's disease.
Intraperitoneal injection at 0.5mg/kg/day completely reversed scopolamine-induced cognitive deficits (p<0.001), with performance indistinguishable from healthy controls.
Dihexa restored spatial learning and memory in Morris water maze tests, increased neuronal cells and synaptophysin expression, reduced neuroinflammation.
Demonstrated to be 10 million times more effective than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
Plain-English guides and study summaries from published literature.
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