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AEDP | Brain Cortex Bioregulator Peptide
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.
Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.
AEDP
Alanine
Position 1
Glutamic Acid
Position 2
Aspartic Acid
Position 3
Proline
Position 4
Shows beneficial long-term results in research following ischemic brain injury.
Research demonstrates effects on restoration of injured nerve function.
Regulates inflammatory response in the nervous system.
Helps regulate immune function by reducing autoimmune reactions.
Stimulates interleukin-2 expression for immune regulation.
Restores balance between pro- and anti-oxidative processes.
Addresses age-related CNS changes through bioregulation.
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable form available for direct administration, bypassing GI tract.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Complementary CNS bioregulators; Cortagen for cortex, Pinealon for general brain.
Often combined in comprehensive anti-aging Khavinson protocols.
Different organ targets; can be used in comprehensive bioregulator protocols.
Part of Khavinson bioregulator family; targets different tissue.
Gene expression modulation begins
Effects persist due to epigenetic changes
Neurological function improvements
Cumulative benefits with periodic cycles
Neuroendocrinology Letters
Cortagen affects expression of genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15 in heart tissue.
Doklady Biological Sciences
Demonstrated effects on nerve function restoration following injury.
Bulletin of Experimental Biology and Medicine
Research on nerve regeneration effects of Cortagen tetrapeptide.
Advances in Gerontology
Comprehensive review of bioregulator peptides and their epigenetic mechanisms.
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