Cerebrolysin Price Comparison

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Best Price R500.00
Average R574.50
Highest R649.00
You Could Save 23%
2 results
Best Price
Save 23%
Crono Pharm logo

Cerebrolysin 60mg

Out of Stock 60mg Lab Tested
R500.00
+ R150.00 delivery
Reschem logo

Cerebrolysin

R649.00
Out of Stock 60mg Lab Tested Pen
FREE over R600

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Cerebrolysin Profile

Well Studied

Neuropeptide Preparation | Neurological Recovery

Overview

Standardized neuropeptide preparation containing bioactive peptides and amino acids exhibiting neurotrophic and neuroprotective properties for stroke recovery, traumatic brain injury, and cognitive enhancement. Used clinically in 50+ countries.

Mechanism of Action

IV/IM administration provides optimal bioavailability and brain penetration of neuropeptides and neurotrophic factors.

Key Benefits

  • Direct brain delivery
  • Standardized dosing
  • Extensive clinical evidence
  • Ready-to-use formulation
  • Used clinically in 50+ countries

Quick Stats

Typical Dose
10-50mL depending on indication (stroke/TBI higher doses)
Frequency
Once daily for acute conditions; 5 days weekly for chronic conditions
Cycle Duration
7-30 days depending on condition (stroke/TBI 10-30 days, dementia 4 weeks)
Storage
Room temperature ≤25°C, protected from light in original carton - never freeze

Molecular Information

Molecular Weight
Variable
Length
Multiple peptides
Type
Purified porcine brain proteins
Half-Life
Minutes (component-dependent; e.g., BDNF ~10 min)

Amino Acid Sequence

Bioactive peptide mixture

Modifications

Standardized neuropeptide preparation

Research Indications

The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research.

Alzheimer's Disease

Moderate

Meta-analyses show modest cognitive improvements, though clinical significance remains debated.

Vascular Dementia

Effective

Multiple RCTs demonstrate significant ADAS-cog and CIBIC+ improvements.

Post-Stroke Cognitive Recovery

Moderate

Large meta-analysis shows significant NIHSS improvements; other studies found no functional benefit.

Acute Stroke

Moderate

Largest meta-analysis (1,879 patients) shows NIHSS benefits; independent analysis found no mRS improvement.

Traumatic Brain Injury

Most Effective

Multiple trials including CAPTAIN series confirm GCS/GOS improvements.

Subarachnoid Hemorrhage

Moderate

Pilot trial shows promising 6-month outcomes; requires larger confirmatory studies.

Motor Function Recovery

Moderate

Some studies show enhanced recovery; results vary significantly between trials.

Neurological Function

Effective

Early administration within 72 hours shows better outcomes than delayed treatment.

Dosing Protocols

injectable

Primary administration route with well-established protocols for direct brain delivery via IV/IM.

Goal Dose Frequency Route
Small Volume IV Up to 10mL Once daily Undiluted IV slow push over 3 minutes
Intramuscular Up to 5mL Once daily Undiluted IM injection over 3 minutes
Acute Stroke 20-50mL Once daily for 10-21 days IV infusion (diluted to 100mL minimum)
Traumatic Brain Injury 20-50mL Once daily for 7-30 days IV infusion (diluted to 100mL minimum)
Alzheimer's Disease 10-30mL 5 days weekly for 4 weeks IV injection/infusion (2-4 cycles yearly)
Vascular Dementia 10-30mL 5 days weekly for 4 weeks IV injection/infusion (2-4 cycles yearly)

Key Tips

  • Direct brain delivery
  • Standardized dosing
  • Optimal bioavailability
  • Extensive clinical documentation
Materials Needed
Cerebrolysin ampoules (5, 10, or 20 mL) Saline, Ringer solution, or 5% glucose (minimum 100 mL for infusion) Disposable one-way IV infusion sets and cannulas Sterile syringes and alcohol swabs
Steps
  1. 1 Break ampoule and extract Cerebrolysin immediately before use
  2. 2 For direct injection: Up to 10 mL IV undiluted (slow 3 minutes) or 5 mL IM
  3. 3 For infusion: Dilute 10-50 mL to minimum 100 mL with compatible solution
  4. 4 Start infusion immediately after dilution—infuse within 15 minutes
  5. 5 Flush IV catheter with sodium chloride before and after administration
  6. 6 Use disposable one-way infusion sets; discard after use

Peptide Interactions

Piracetam

Compatible

Safe combination with no significant interactions; both support cognitive function.

Donepezil

Compatible

No interactions reported; may have synergistic cognitive effects in Alzheimer's treatment.

SSRIs

Monitor

Potential additive neurotropic effects; monitor for enhanced antidepressant effects.

Tricyclic Antidepressants

Monitor

May have additive neurological effects; requires careful monitoring.

Amino Acid Solutions

Avoid

Contraindicated per prescribing information; do not mix in same infusion.

Cardiovascular Medications

Avoid

Should not be mixed in same IV infusion per official guidelines.

Vitamin Solutions

Avoid

Compatibility issues; do not mix in same IV infusion.

Noopept

Monitor

Both enhance neurotrophic factors; potential additive effects—start with lower doses.

What to Expect

Week 1-2

Initial neuroprotective effects; possible mild side effects (dizziness, agitation)

Week 2-4

Neurological improvements become apparent; cognitive function may begin to improve

Week 4-8

Continued recovery; motor function improvements in stroke/TBI patients

Week 8-12

Sustained benefits; cognitive enhancement plateaus in chronic conditions

Side Effects & Safety

Common Side Effects

  • Generally well tolerated
  • Possible mild dizziness or agitation in early treatment

Monitoring

  • Monitor for allergic reactions during first dose
  • Renal function in patients with kidney disease
  • Seizure activity in at-risk patients
  • Cardiovascular status during administration

Stop Signs

  • Severe allergic reactions (anaphylaxis, severe rash)
  • New onset seizure activity
  • Significant cardiovascular events during administration
  • Severe renal dysfunction or worsening kidney function

Contraindications

  • Epilepsy
  • Severe renal insufficiency
  • History of severe allergic reactions to porcine products

Quality Checklist

Good Signs

  • Clear amber solution from reputable source
  • Room temperature storage ≤25°C
  • Protected from light in original carton
  • Authorized EVER Pharma distributor

Warning Signs

  • Some published studies have been retracted due to research misconduct; rely on independent meta-analyses

Bad Signs

  • Frozen product or improper storage—never freeze
  • Mixing with incompatible solutions (amino acids, vitamins, cardiovascular medications)

Research & References

Key References

  1. 2020

    CAPTAIN II Trial - Traumatic Brain Injury

    Randomized controlled trial demonstrating efficacy and safety in moderate-severe TBI with improved GCS and GOS scores.

  2. 2017

    Nine-Trial Stroke Meta-Analysis - Positive Results

    Largest positive meta-analysis showing significant neurological improvements in 1,879 stroke patients with NNT=7.7.

  3. 2017

    Conflicting Stroke Meta-Analysis - Neutral Results

    Independent meta-analysis of 1,779 patients found no significant benefits in functional outcomes (mRS/BI).

  4. 2023

    TBI Systematic Review - Positive Outcomes

    Analysis of 8,749 TBI patients across 10 studies confirms statistically significant GCS/GOS improvements.

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