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Compare 2 prices for 5-Amino 1MQ. Cheapest: R700.00. Average: R825.00.
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Limitless Peptides
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5-Amino 1MQ 5mg |
R700.00 | R140.00/mg | In Stock | R90.00 |
Lab Tested
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5-Amino 1MQ 5mg |
R950.00 | R190.00/mg | In Stock | R150.00 |
Lab Tested
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NNMT Inhibitor | Longevity & Metabolic Enhancement
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Improvement through enhanced mitochondrial efficiency.
Enhancement via cellular energy optimization.
Improved glucose/fat substrate switching.
Supports increased basal metabolic rate.
Improvements in fat burning capacity.
Most common delivery method. Take with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels. Morning or early afternoon dosing preferred.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative initiation | 25mg | 1x daily | Oral with food |
| Standard starting dose | 50mg | 1x daily | Oral with food |
| Typical maintenance | 75mg | 1x daily | Oral with food |
| Maximum dose | 100mg | 1x daily | Oral with food |
| Split dosing protocol | 50mg | 2x daily | Oral with meals |
Injectable protocols exist but vary widely. CRITICAL: Two vastly different protocols exist differing by 100-200x depending on units (mcg vs mg). Verify units before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative starting (mcg protocol) | 150-250mcg | 1x daily | SubQ |
| Conservative standard (mcg protocol) | 250-500mcg | 1x daily | SubQ |
| Study-based (mg protocol) | ~350mg (5mg/kg) | 1x daily | SubQ |
May work synergistically by preventing breakdown while supporting production.
Both support longevity; resveratrol activates sirtuins while 5-Amino-1MQ provides NAD+ substrate.
Both affect metabolic pathways; combination may enhance effects but requires careful monitoring.
No known interactions; different mechanisms with potential complementary benefits.
Limited interaction data; consult healthcare provider before combining.
Both affect metabolic pathways; potential additive glucose metabolism effects.
Gradual energy increase and mental clarity
Enhanced exercise performance and recovery
Improved metabolic markers and body composition
Sustained longevity benefits and cellular health improvements
Nature Reviews Drug Discovery
Comprehensive review of NNMT inhibition for metabolic disease and aging interventions.
Cell Metabolism
Role of NAD+ metabolism in healthy aging and therapeutic interventions.
Diet-induced obese mice showed 5.1% weight loss, 30% adipocyte size reduction at 60mg/kg/day. Human equivalent ~5mg/kg/day using FDA allometric scaling.
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Supports oral administration viability.
40% grip strength improvement in sedentary mice, 60% with exercise at 10mg/kg/day SubQ for 8 weeks. No adverse effects observed.
Plain-English guides and study summaries from published literature.
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