--- title: "Guides - Peptide Research & Guides - PeptideSupermarket®" description: "Peptide Guides from published scientific literature. Plain-English articles, study summaries and safety notes, without the fluff." url: "https://peptidesupermarket.co.za/research/category/guides" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › Research Research & Guides # Guides Plain-English guides, study summaries and safety notes from published scientific literature — **76 articles** and counting. Reference-backed Updated regularly Zero medical advice All content is for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). Library ## Guides 76 articles available. [All 76](https://peptidesupermarket.co.za/research) [Guides 76](https://peptidesupermarket.co.za/research/category/guides) Guides 9 min GHK-Cu ### GHK-Cu vs Regular Skincare Peptides: What's the Difference? GHK-Cu is a copper-binding peptide with a broader skin repair research profile than many cosmetic peptides. Here is how it compares with Matrixyl, Argireline, SNAP-8 and similar ingredients. 10 Oct 2026 Read [GHK-Cu vs Regular Skincare Peptides: What's the Difference?](https://peptidesupermarket.co.za/research/ghk-cu-vs-regular-skincare-peptides-whats-the-difference) Guides 7 min Retatrutide ### 30mg vs 60mg Retatrutide: what the label actually means A 60mg Retatrutide product contains twice the stated peptide quantity of a 30mg product, but that does not make it twice as effective or automatically better value. Here is how to read the numbers properly. 9 Oct 2026 Read [30mg vs 60mg Retatrutide: what the label actually means](https://peptidesupermarket.co.za/research/30mg-vs-60mg-retatrutide-what-the-label-actually-means) Guides 10 min Ipamorelin ### Ipamorelin guide: mechanism, benefits, stacking and safety A research-focused guide to Ipamorelin, covering its ghrelin receptor mechanism, growth hormone pulses, CJC-1295 NoDAC pairing, reported benefits, cycling logic and safety caveats. 19 Sep 2026 Read [Ipamorelin guide: mechanism, benefits, stacking and safety](https://peptidesupermarket.co.za/research/ipamorelin-guide-mechanism-benefits-stacking-and-safety) Guides 8 min Mots-C ### MOTS-c peptide guide: mitochondrial signalling, metabolism and exercise research MOTS-c is a mitochondrial-derived peptide studied for metabolic signalling, insulin sensitivity, mitochondrial function and exercise performance. Here is what current research-focused discussion supports, and where caution is needed. 19 Sep 2026 Read [MOTS-c peptide guide: mitochondrial signalling, metabolism and exercise research](https://peptidesupermarket.co.za/research/mots-c-peptide-guide-mitochondrial-signalling-metabolism-and-exercise-research) Guides 7 min KPV ### KPV Peptide SA Guide: Mechanism, Research Uses and Buying Considerations KPV is an alpha-MSH fragment studied mainly for anti-inflammatory signalling, gut health and skin inflammation. This guide explains its mechanism, research status and sourcing considerations in South Africa. 19 Sep 2026 Read [KPV Peptide SA Guide: Mechanism, Research Uses and Buying Considerations](https://peptidesupermarket.co.za/research/kpv-peptide-sa-guide-mechanism-research-uses-and-buying-considerations) Guides 10 min Retatrutide ### Retatrutide dosing: a minimum effective dose guide for research A research-focused guide to Retatrutide dosing, covering triple agonist effects, slower titration, functional checkpoints and why 12 mg should not be treated as the default target. 13 Sep 2026 Read [Retatrutide dosing: a minimum effective dose guide for research](https://peptidesupermarket.co.za/research/retatrutide-dosing-a-minimum-effective-dose-guide-for-research) Guides 9 min KPV ### KPV peptide guide: NF-κB, inflammation and the limits of the evidence KPV peptide is a small alpha-MSH fragment studied for anti-inflammatory signalling, especially NF-κB inhibition. This guide separates the pre-clinical evidence from weight loss and wellness claims. 13 Sep 2026 Read [KPV peptide guide: NF-κB, inflammation and the limits of the evidence](https://peptidesupermarket.co.za/research/kpv-peptide-guide-nf-kb-inflammation-and-the-limits-of-the-evidence) Guides 6 min PNC-27 ### PNC-27 Peptide Guide: Mechanism, Research Status and Safety Context PNC-27 is an experimental peptide studied for cancer-cell selectivity through HDM-2 binding and membrane pore formation. It remains a research compound, with no approved human protocol. 13 Sep 2026 Read [PNC-27 Peptide Guide: Mechanism, Research Status and Safety Context](https://peptidesupermarket.co.za/research/pnc-27-peptide-guide-mechanism-research-status-and-safety-context) Guides 7 min Ipamorelin ### Ipamorelin peptide guide for GH signalling, recovery and body composition Ipamorelin is a selective growth hormone secretagogue studied for GH release pathways, recovery, sleep and body composition. This guide explains its mechanism, realistic research claims and key safety limits. 12 Sep 2026 Read [Ipamorelin peptide guide for GH signalling, recovery and body composition](https://peptidesupermarket.co.za/research/ipamorelin-peptide-guide-for-gh-signalling-recovery-and-body-composition) Guides 6 min Semax ### Semax Peptide Guide: Cognitive Enhancement, BDNF and Research Use Semax is a synthetic ACTH-derived heptapeptide studied for focus, memory, BDNF signalling and neuroprotection. This guide explains what the research discussion supports and where caution is needed. 6 Sep 2026 Read [Semax Peptide Guide: Cognitive Enhancement, BDNF and Research Use](https://peptidesupermarket.co.za/research/semax-peptide-guide-cognitive-enhancement-bdnf-and-research-use) Guides 6 min Selank ### Selank Peptide Guide: Anxiety, Cognition and Research Uses Selank is a synthetic tuftsin analogue studied for anxiety-related models, cognition, stress resilience and immune signalling. Here is what researchers need to know. 6 Sep 2026 Read [Selank Peptide Guide: Anxiety, Cognition and Research Uses](https://peptidesupermarket.co.za/research/selank-peptide-guide-anxiety-cognition-and-research-uses) Guides 7 min Pinealon ### Pinealon: Sleep, Brain Fog and the Research Behind the EDR Peptide Pinealon, also known as EDR, is a synthetic tripeptide studied for neuroprotection, cognitive resilience and ageing-related brain health. The evidence is interesting, but still needs careful interpretation. 5 Sep 2026 Read [Pinealon: Sleep, Brain Fog and the Research Behind the EDR Peptide](https://peptidesupermarket.co.za/research/pinealon-sleep-brain-fog-and-the-research-behind-the-edr-peptide) --- *Add `.md` to any page URL on peptidesupermarket.co.za for its Markdown version. Index of the site: https://peptidesupermarket.co.za/llms.txt - full text: https://peptidesupermarket.co.za/llms-full.txt.*