--- title: "VIP Peptide SA - Compare Prices from 7 Suppliers - PeptideSupermarket®" description: "Compare VIP prices from 7 SA suppliers, from R490.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.za/peptide/vip" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › [Peptides](https://peptidesupermarket.co.za/compare-peptide-prices-za) › VIP Search # VIP Price Comparison Live prices from 7 SA suppliers, from R490.00, compared side by side so you never overpay. [Immune signalling](https://peptidesupermarket.co.za/compare-peptide-prices-za) Prices checked 48 minutes ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.za/disclosure). Best Price R700.00 Average R1,139.71 Highest R1,608.85 You Could Save 56% 4 results 10mg Compare 4 prices for VIP. Cheapest: R700.00. Average: R1,139.71. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | [Crono Pharm](https://peptidesupermarket.co.za/suppliers/chrono-pharm) Best VIP | R700.00 | R70.00/mg | In Stock | R150.00 | Lab Tested | — | Visit | | | [Striata Labs](https://peptidesupermarket.co.za/suppliers/striata-labs) VIP 10mg | R900.00 | R90.00/mg | In Stock | R150.00 | Lab Tested | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) VIP 10mg | R1,350.00 | R135.00/mg | In Stock | R170.00 | — | — | Visit | | | [Pure Performance Labs](https://peptidesupermarket.co.za/suppliers/pure-performance-labs) VIP 10mg | R1,608.85 | R160.89/mg | In Stock | R250.00 | Lab Tested | — | Visit | More ways to compare VIP Different views of the same live SA pricing, tuned for how you like to shop. [Best VIP Prices Best prices ranked](https://peptidesupermarket.co.za/best-vip-prices) [Cheapest VIP Prices Cheapest suppliers compared](https://peptidesupermarket.co.za/cheapest-vip-prices) [Where to Buy VIP Full buyer's guide](https://peptidesupermarket.co.za/where-to-buy-vip) [Buy VIP Online SA Cheap Today's hottest deals](https://peptidesupermarket.co.za/buy-vip-online-za-cheap) [VIP Price Comparison Live price dashboard](https://peptidesupermarket.co.za/vip-price-comparison) [VIP SA Supplier Verified SA supplier directory](https://peptidesupermarket.co.za/vip-za-supplier) [VIP For Sale Browse listings for sale](https://peptidesupermarket.co.za/vip-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). ## VIP Profile Extensively Studied Vasoactive Intestinal Peptide | Neuropeptide ### Overview Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. It is produced in many tissues including the gut, pancreas, and brain. VIP has potent vasodilatory, anti-inflammatory, and immunomodulatory effects. It binds to VPAC1 and VPAC2 receptors, triggering cAMP-mediated signaling cascades. Research shows therapeutic potential for pulmonary hypertension, diabetes, neurological disorders, and autoimmune conditions. ### Mechanism of Action VIP binds to VPAC1 and VPAC2 G protein-coupled receptors, activating adenylyl cyclase and increasing intracellular cAMP and PKA activity. This triggers phosphorylation of CREB and other transcription factors. VIP causes vasodilation through NO-dependent and independent mechanisms, stimulates intestinal secretion, relaxes smooth muscle, inhibits gastric acid secretion, and has positive inotropic/chronotropic cardiac effects. ### Key Benefits - Potent vasodilation and blood pressure reduction - Strong anti-inflammatory effects - Immunomodulation (Th1-Th2 balance) - Neuroprotective effects - Bronchodilation - Cardioprotective (positive inotropic effects) - Insulin secretion enhancement (glucose-dependent) - Gut barrier and permeability regulation ### Quick Stats Typical Dose 50-100 mcg per dose (up to 200 mcg in research protocols) Frequency 1-2 times daily due to very short 2-minute half-life Cycle Duration As prescribed for specific condition Storage Lyophilized powder: 2-8°C refrigerated; Reconstituted: use immediately (very short stability, ~2 minute half-life) ## Molecular Information Molecular Weight 3,326 Da Length 28 amino acids Type Neuropeptide Half-Life 1-2 minutes ### Amino Acid Sequence One-letter: `HSDAVFTDNYTRLRKQMAVKKYLNSILN?` His 1 Histidine Position 1 Ser 2 Serine Position 2 Asp 3 Aspartic Acid Position 3 Ala 4 Alanine Position 4 Val 5 Valine Position 5 Phe 6 Phenylalanine Position 6 Thr 7 Threonine Position 7 Asp 8 Aspartic Acid Position 8 Asn 9 Asparagine Position 9 Tyr 10 Tyrosine Position 10 Thr 11 Threonine Position 11 Arg 12 Arginine Position 12 Leu 13 Leucine Position 13 Arg 14 Arginine Position 14 Lys 15 Lysine Position 15 Gln 16 Glutamine Position 16 Met 17 Methionine Position 17 Ala 18 Alanine Position 18 Val 19 Valine Position 19 Lys 20 Lysine Position 20 Lys 21 Lysine Position 21 Tyr 22 Tyrosine Position 22 Leu 23 Leucine Position 23 Asn 24 Asparagine Position 24 Ser 25 Serine Position 25 Ile 26 Isoleucine Position 26 Leu 27 Leucine Position 27 Asn 28 Asparagine Position 28 NH2 29 NH2 Position 29 N-terminus C-terminus Hydrophobic Polar Positive (+) Negative (-) Modified ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Cardiovascular Neurological Metabolic & Immune ## Dosing Protocols ### injectable VIP has a very short half-life of approximately 2 minutes in blood, requiring careful dosing strategies. Subcutaneous or intravenous administration. Rapid degradation limits bioavailability; analogs like stearyl-Nle17-VIP (SNV) are 100-fold more potent. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | General use | 50-100 mcg | 1-2x daily | SubQ or IV | | Research protocols | 100-200 mcg | As directed | SubQ or IV | #### Key Tips - Very short half-life (~2 minutes) - Multiple daily doses may be needed - Analogs offer improved stability Reconstitution Instructions ### nasal Inhalation route researched for pulmonary hypertension. Safety demonstrated in healthy and asthmatic subjects at 100 μM concentrations. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Pulmonary hypertension | 100-200 mcg/day | Daily (inhaled) | Inhalation | #### Key Tips - Targeted delivery to lungs - Effective for pulmonary conditions - Non-invasive ## Peptide Interactions #### BPC-157 Compatible No known negative interactions; different mechanisms. #### Thymosin Alpha-1 Synergistic Both have immunomodulatory effects; may complement each other. #### LL-37 Compatible Both have anti-inflammatory properties. ## What to Expect Minutes Rapid vasodilation and hemodynamic effects Hours Anti-inflammatory signaling activated Days-Weeks Cumulative effects on inflammation and immune balance Ongoing Sustained benefits with regular administration ## Side Effects & Safety #### Common Side Effects - Vasodilation (flushing, warmth) - Hypotension - Increased heart rate - Gastrointestinal effects (diarrhea possible) - Headache #### Stop Signs - Severe hypotension - Allergic reaction symptoms - Severe diarrhea - Cardiac arrhythmias #### Contraindications - Severe hypotension - VIPoma or related tumors - Pregnancy or breastfeeding - Severe cardiac conditions ## Quality Checklist #### Good Signs - White lyophilized powder - Clear solution after reconstitution - Intact vacuum seal #### Warning Signs - Use quickly after reconstitution (unstable) #### Bad Signs - Discolored powder - Cloudy solution - Particulates visible ## Research & References ### Key References 1. 2003 #### VIP as New Drug for Treatment of Primary Pulmonary Hypertension Journal of Clinical Investigation VIP inhalation showed striking efficacy with increased mixed venous oxygen saturation and exercise capacity. 2. 2022 #### Therapeutic Potential of VIP and VPAC2 in Type 2 Diabetes Frontiers in Endocrinology VIP promotes glucose-dependent insulin secretion via VPAC2, reducing hypoglycemia risk. 3. 2010 #### Therapeutic Potential of VIP in Neurological Disorders CNS Neuroscience & Therapeutics VIP and receptors are promising therapeutic targets for AD, PD, and autism spectrum disorders. 4. 2011 #### VIP Structure and Function for Therapeutic Applications Pharmacology & Therapeutics Comprehensive review of VIP receptor signaling and therapeutic applications. [Search PubMed for VIP](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22VIP%22%20OR%20%22Vasoactive%20Intestinal%20Polypeptide%22%20OR%20%22PHM-27%22%29) Research Library ## VIP research & guides Plain-English guides and study summaries from published literature. [View all 2](https://peptidesupermarket.co.za/research/peptide/vip) ![VIP Peptide Guide: Circulation, Inflammation and Immune Signalling](https://peptidesupermarket.co.za/storage/1412/conversions/VIP-Image-PEPSUPSA-Image-thumbnail.jpg) Guides 8 min ### VIP Peptide Guide: Circulation, Inflammation and Immune Signalling VIP is a widely studied neuropeptide involved in vascular tone, airway biology, immune signalling and circadian regulation. This guide explains what the research can and cannot support. Read article [VIP Peptide Guide: Circulation, Inflammation and Immune Signalling](https://peptidesupermarket.co.za/research/vip-peptide-guide-circulation-inflammation-and-immune-signalling) ![VIP Peptide South Africa: Research Guide to Vasoactive Intestinal Peptide](https://peptidesupermarket.co.za/storage/1354/conversions/VIP-Image-PEPSUPAM-thumbnail.jpg) Guides 6 min ### VIP Peptide South Africa: Research Guide to Vasoactive Intestinal Peptide VIP is a 28-amino acid neuropeptide studied for vascular tone, immune signalling, respiratory function and neurological pathways. This guide explains the research without overstating its use. Read article [VIP Peptide South Africa: Research Guide to Vasoactive Intestinal Peptide](https://peptidesupermarket.co.za/research/vip-peptide-south-africa-research-guide-to-vasoactive-intestinal-peptide) --- *Add `.md` to any page URL on peptidesupermarket.co.za for its Markdown version. Index of the site: https://peptidesupermarket.co.za/llms.txt - full text: https://peptidesupermarket.co.za/llms-full.txt.*