--- title: "Semaglutide Peptide SA - Compare Prices from 10 Suppliers - PeptideSupermarket®" description: "Compare Semaglutide prices from 10 SA suppliers, from R550.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.za/peptide/semaglutide" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › [Peptides](https://peptidesupermarket.co.za/compare-peptide-prices-za) › Semaglutide Search # Semaglutide Price Comparison Live prices from 10 SA suppliers, from R550.00, compared side by side so you never overpay. [GLP-1 & metabolic research](https://peptidesupermarket.co.za/compare-peptide-prices-za) Prices checked 1 hour ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.za/disclosure). Best Price R649.00 Average R1,287.80 Highest R1,600.00 You Could Save 59% 5 results 10mg Compare 5 prices for Semaglutide. Cheapest: R649.00. Average: R1,287.80. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | [JP Research](https://peptidesupermarket.co.za/suppliers/jp-research) Best Semaglutide | R649.00 | R64.90/mg | In Stock | Free | Lab Tested | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) Semaglutide 10mg | R1,290.00 | R129.00/mg | In Stock | R170.00 | — | — | Visit | | | [Seranova](https://peptidesupermarket.co.za/suppliers/seranova) Semaglutide 10mg | R1,350.00 | R135.00/mg | In Stock | R250.00 | — | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) Semaglutide 10mg | R1,550.00 | R155.00/mg | In Stock | R170.00 | — | — | Visit | | | [BioPeptics](https://peptidesupermarket.co.za/suppliers/biopeptics) Semaglutide 10mg | R1,600.00 | R160.00/mg | In Stock | R150.00 | — | — | Visit | More ways to compare Semaglutide Different views of the same live SA pricing, tuned for how you like to shop. [Best Semaglutide Prices Best prices ranked](https://peptidesupermarket.co.za/best-semaglutide-prices) [Cheapest Semaglutide Prices Cheapest suppliers compared](https://peptidesupermarket.co.za/cheapest-semaglutide-prices) [Where to Buy Semaglutide Full buyer's guide](https://peptidesupermarket.co.za/where-to-buy-semaglutide) [Buy Semaglutide Online SA Cheap Today's hottest deals](https://peptidesupermarket.co.za/buy-semaglutide-online-za-cheap) [Semaglutide Price Comparison Live price dashboard](https://peptidesupermarket.co.za/semaglutide-price-comparison) [Semaglutide SA Supplier Verified SA supplier directory](https://peptidesupermarket.co.za/semaglutide-za-supplier) [Semaglutide For Sale Browse listings for sale](https://peptidesupermarket.co.za/semaglutide-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). ## Semaglutide Profile Fda Approved FDA Approved GLP-1 Receptor Agonist | Weight Loss & Diabetes ### Overview Long-acting GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management. Over 17,000 trial participants have demonstrated significant efficacy through appetite suppression and glycemic control. The 7-day half-life enables convenient weekly dosing. ### Mechanism of Action Mimics native GLP-1, binding to receptors to stimulate glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite via hypothalamic pathways. ### Key Benefits - 15-20% average body weight reduction - Established cardiovascular protection - Convenient once-weekly dosing options - Comprehensive safety data from extensive trials - Flexible injectable and oral formulations ### Quick Stats Typical Dose 0.25mg starting, titrate to 1-2.4mg weekly Frequency Once weekly (same day each week) Cycle Duration Ongoing therapy as prescribed Storage Pen: 2-8°C before first use, room temp up to 56 days after. Compounded: 2-8°C ## Molecular Information Molecular Weight 4,113.64 Da Length 31 amino acids Type GLP-1 receptor agonist Half-Life ~7 days (168 hours) ### Amino Acid Sequence One-letter: `HUEGTFTSDVSSYLEGQAAKEFIAWLVRGRG` His 1 Histidine Position 1 Aib 2 Aminoisobutyric Acid Position 2 Glu 3 Glutamic Acid Position 3 Gly 4 Glycine Position 4 Thr 5 Threonine Position 5 Phe 6 Phenylalanine Position 6 Thr 7 Threonine Position 7 Ser 8 Serine Position 8 Asp 9 Aspartic Acid Position 9 Val 10 Valine Position 10 Ser 11 Serine Position 11 Ser 12 Serine Position 12 Tyr 13 Tyrosine Position 13 Leu 14 Leucine Position 14 Glu 15 Glutamic Acid Position 15 Gly 16 Glycine Position 16 Gln 17 Glutamine Position 17 Ala 18 Alanine Position 18 Ala 19 Alanine Position 19 Lys 20 Lysine Position 20 Glu 21 Glutamic Acid Position 21 Phe 22 Phenylalanine Position 22 Ile 23 Isoleucine Position 23 Ala 24 Alanine Position 24 Trp 25 Tryptophan Position 25 Leu 26 Leucine Position 26 Val 27 Valine Position 27 Arg 28 Arginine Position 28 Gly 29 Glycine Position 29 Arg 30 Arginine Position 30 Gly 31 Glycine Position 31 N-terminus C-terminus Hydrophobic Polar Positive (+) Negative (-) Modified ### Modifications Acylated with C18 fatty diacid via γ-Glu spacer ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Weight Loss Diabetes Metabolic ## Dosing Protocols ### injectable Pre-filled pen devices for once-weekly subcutaneous injection. Brands include Ozempic (diabetes) and Wegovy (weight loss). | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Weight Loss Initiation | 0.25mg | Weekly x 4 weeks, then increase | Subcutaneous | | Weight Loss Maintenance | 2.4mg | Weekly (after 16-week titration) | Subcutaneous | | Diabetes Management | 0.5-1mg | Weekly | Subcutaneous | | Cardiovascular Protection | 0.5-1mg | Weekly | Subcutaneous | | Tolerability-Based | 0.25-2.4mg | Weekly (individualized) | Subcutaneous | #### Key Tips - Once-weekly dosing - Abdomen, thigh, or upper arm injection sites - Pre-filled pens available Reconstitution Instructions ### oral Rybelsus tablets use SNAC technology for enhanced absorption. Requires strict administration protocol. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Diabetes Initiation | 3mg | Daily x 30 days | Oral (empty stomach) | | Standard Diabetes Dose | 7mg | Once daily | Oral (empty stomach) | | Maximum Diabetes Dose | 14mg | Once daily | Oral (empty stomach) | #### Key Tips - No injection required - Daily dosing maintains consistent levels - SNAC technology enhances absorption Reconstitution Instructions ## Peptide Interactions #### Insulin Monitor May increase hypoglycemia risk when combined; requires blood glucose monitoring. #### Tirzepatide Avoid Both are incretin mimetics with overlapping mechanisms; concurrent use increases side effects. #### Cagrilintide Synergistic Combined as CagriSema in clinical trials for enhanced weight loss efficacy. #### Metformin Compatible Commonly used together for diabetes management with good safety profile. #### BPC-157 Compatible No contraindications; may help with GI side effects. #### Sulfonylureas Monitor Increased hypoglycemia risk; may require sulfonylurea dose reduction. #### Oral Medications Requires Timing Delayed gastric emptying may affect absorption of oral medications. ## What to Expect Week 1-4 Mild appetite reduction, possible nausea during initial dose Month 2-3 Noticeable weight loss (5-10% typical), improved satiety Month 4-6 Continued weight loss (10-15% common), stable glucose levels Month 6+ Weight loss plateau possible, focus on maintenance Diabetes Blood sugar improvements within 1-2 weeks ## Side Effects & Safety #### Common Side Effects - Nausea - Diarrhea - Vomiting - Constipation - Abdominal pain #### Monitoring - Blood glucose levels - Signs of pancreatitis - Thyroid nodules - Kidney function #### Stop Signs - Severe persistent abdominal pain (possible pancreatitis) - Persistent vomiting preventing fluid intake - Signs of thyroid tumor (neck lump, hoarseness, trouble swallowing) - Severe allergic reaction (rash, itching, difficulty breathing) - Vision changes (possible diabetic retinopathy progression) - Severe hypoglycemia (if combined with insulin/sulfonylureas) - Kidney problems (decreased urination, swelling) #### Contraindications - Personal or family history of medullary thyroid cancer - Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) - Pregnancy or breastfeeding - History of pancreatitis ## Quality Checklist #### Good Signs - FDA-approved branded products (Ozempic, Wegovy, Rybelsus) - Proper refrigeration verified and not expired - Clear, colorless to slightly yellow solution in pen/vial #### Warning Signs - Compounded versions - FDA warns about untested compounded semaglutide #### Bad Signs - Cloudy or discolored solution - Particles or precipitation visible - Non-pharmacy sources or unverified online sellers ## Research & References ### Key References 1. 2021 #### STEP 1 Trial - Weight Management 14.9% average weight loss versus 2.4% with placebo over 68 weeks with 2.4mg weekly. 2. 2023 #### SELECT Cardiovascular Outcomes 20% reduction in major adverse cardiovascular events over 5 years with 2.4mg weekly. 3. 2016 #### SUSTAIN Diabetes Program Average HbA1c reductions of 1.5-1.8% across multiple trials. 4. 2022 #### STEP 5 Two-Year Maintenance Sustained weight loss of 15.2% at week 104 with 2.4mg weekly. 5. 2019 #### PIONEER Oral Semaglutide Oral efficacy comparable to injectable formulations at 3-14mg daily. 6. 2022 #### STEP TEENS Adolescent Study 16.1% BMI reduction in adolescent population over 68 weeks. [Search PubMed for Semaglutide](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22Semaglutide%22%20OR%20%22Ozempic%22%20OR%20%22Wegovy%22%20OR%20%22Rybelsus%22%29) Research Library ## Semaglutide research & guides Plain-English guides and study summaries from published literature. [View all 2](https://peptidesupermarket.co.za/research/peptide/semaglutide) ![Semaglutide in South Africa: GLP-1 Research, Weight Loss and Cartilage Questions](https://peptidesupermarket.co.za/storage/1398/conversions/Semaglutide-Pepsup-image-thumbnail.jpg) Guides 6 min ### Semaglutide in South Africa: GLP-1 Research, Weight Loss and Cartilage Questions Semaglutide has strong evidence in type 2 diabetes and chronic weight management. Newer cartilage research is interesting, but still early and should not be overstated. Read article [Semaglutide in South Africa: GLP-1 Research, Weight Loss and Cartilage Questions](https://peptidesupermarket.co.za/research/semaglutide-in-south-africa-glp-1-research-weight-loss-and-cartilage-questions) ![Semaglutide South Africa: Weight Loss, Appetite and Muscle Loss Explained](https://peptidesupermarket.co.za/storage/1383/conversions/Semaglutide-Pepsup-image-thumbnail.jpg) Guides 8 min ### Semaglutide South Africa: Weight Loss, Appetite and Muscle Loss Explained Semaglutide is a well-studied GLP-1 receptor agonist linked to weight loss, appetite control and metabolic benefits. Here is what the evidence says, and what to consider when comparing products in South Africa. Read article [Semaglutide South Africa: Weight Loss, Appetite and Muscle Loss Explained](https://peptidesupermarket.co.za/research/semaglutide-south-africa-weight-loss-appetite-and-muscle-loss-explained) --- *Add `.md` to any page URL on peptidesupermarket.co.za for its Markdown version. 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