--- title: "PNC-27 Peptide SA - Compare Prices from 6 Suppliers - PeptideSupermarket®" description: "Compare PNC-27 prices from 6 SA suppliers, from R550.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.za/peptide/pnc-27" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › [Peptides](https://peptidesupermarket.co.za/compare-peptide-prices-za) › PNC-27 Search # PNC-27 Price Comparison Live prices from 6 SA suppliers, from R550.00, compared side by side so you never overpay. Prices checked 1 hour ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.za/disclosure). Best Price R550.00 Average R1,075.50 Highest R1,659.00 You Could Save 67% 6 results 5mg Compare 6 prices for PNC-27. Cheapest: R550.00. Average: R1,075.50. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | [SA Peptides](https://peptidesupermarket.co.za/suppliers/sa-peptides) Best PNC-27 5mg | R550.00 | R110.00/mg | In Stock | R140.00 | — | — | Visit | | | [Buy Peptides](https://peptidesupermarket.co.za/suppliers/buy-peptides) PNC-27 5mg | R550.00 | R110.00/mg | In Stock | R250.00 | — | — | Visit | | | [Reschem](https://peptidesupermarket.co.za/suppliers/reschem) PNC-27 Pen | R859.00 | R171.80/mg | Out of Stock | Free over R600 | Lab Tested | — | Visit | | | [Helix Collective](https://peptidesupermarket.co.za/suppliers/helix-collective) PNC-27 5mg | R1,350.00 | R270.00/mg | In Stock | R170.00 | — | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) PNC-27 5mg | R1,485.00 | R297.00/mg | In Stock | R170.00 | — | — | Visit | | | [Impact Nutrition](https://peptidesupermarket.co.za/suppliers/impact-nutrition) PNC-27 5mg | R1,659.00 | R331.80/mg | In Stock | R250.00 | — | — | Visit | More ways to compare PNC-27 Different views of the same live SA pricing, tuned for how you like to shop. [Best PNC-27 Prices Best prices ranked](https://peptidesupermarket.co.za/best-pnc-27-prices) [Cheapest PNC-27 Prices Cheapest suppliers compared](https://peptidesupermarket.co.za/cheapest-pnc-27-prices) [Where to Buy PNC-27 Full buyer's guide](https://peptidesupermarket.co.za/where-to-buy-pnc-27) [Buy PNC-27 Online SA Cheap Today's hottest deals](https://peptidesupermarket.co.za/buy-pnc-27-online-za-cheap) [PNC-27 Price Comparison Live price dashboard](https://peptidesupermarket.co.za/pnc-27-price-comparison) [PNC-27 SA Supplier Verified SA supplier directory](https://peptidesupermarket.co.za/pnc-27-za-supplier) [PNC-27 For Sale Browse listings for sale](https://peptidesupermarket.co.za/pnc-27-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). ## PNC-27 Profile Emerging Anti-Cancer Peptide | p53-HDM-2 Disruptor ### Overview PNC-27 is an experimental anti-cancer peptide created by a supercomputer at SUNY Downstate Medical Center in 2000. It contains an HDM-2 binding domain from p53 (residues 12-26) linked to a cell-penetrating domain. The peptide selectively kills cancer cells by binding to HDM-2 (MDM2) expressed on cancer cell membranes, forming pores that cause cell necrosis. Critically, PNC-27 has no effect on normal cells because healthy cells don't express HDM-2 on their membranes. Research shows effectiveness against pancreatic cancer, breast cancer, leukemia, and melanoma. ### Mechanism of Action PNC-27 exploits a unique vulnerability of cancer cells: the presence of HDM-2 (human double minute 2, also called MDM2) on their cell surface. The peptide's p53 residues adopt a conformation that binds directly to membrane-bound HDM-2, inducing transmembrane pore formation. This causes rapid tumor cell necrosis (not apoptosis). Additionally, PNC-27 enters cancer cells and disrupts mitochondrial membranes. Normal cells lack surface HDM-2 expression and are completely spared. ### Key Benefits - Selectively kills cancer cells only - No effect on normal healthy cells - Induces rapid cancer cell necrosis - Works on multiple cancer types - Unique membrane pore mechanism - Does not require p53 function in target cells - Eradicates tumors in mouse models - Spares human stem cells ### Quick Stats Typical Dose Not established - preclinical research only Frequency Research protocols vary by study Cycle Duration Not established - no human clinical trials Storage Refrigerate at 2-8°C ## Molecular Information Molecular Weight ~3,500 Da Type Chimeric peptide Half-Life Less than 24 hours (requires daily dosing in studies) ### Modifications p53 binding domain (residues 12-26) Transmembrane-penetrating domain ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Cancer Research Mechanism Studies ## Dosing Protocols ### injectable PNC-27 is currently in preclinical research stages. All dosing data comes from in vitro and animal model studies. No human dosing protocols have been approved. The peptide has shown tumor eradication in nude mice xenograft models. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Research protocol | Variable by study | Research protocols | IP or direct tumor injection (research) | #### Key Tips - Cancer cell selectivity - Spares normal cells - Promising preclinical results Reconstitution Instructions ## Peptide Interactions #### Chemotherapy agents Unknown Potential for combination therapy being researched. #### Other anti-cancer peptides Unknown Combination studies not yet published. ## What to Expect Hours Binding to membrane HDM-2 begins Hours-Days Pore formation and cancer cell necrosis Days-Weeks Tumor reduction in animal models Research ongoing Human clinical trials not yet conducted ## Side Effects & Safety #### Common Side Effects - Limited data - primarily preclinical research - Generally well-tolerated in animal studies #### Monitoring - Research compound - medical supervision essential - No human clinical trials completed #### Stop Signs - Not applicable - not approved for human use #### Contraindications - Not approved for human use - Experimental research peptide only - Cancers without membrane HDM-2 may not respond ## Quality Checklist #### Good Signs - White lyophilized powder - High purity (>95%) - Clear solution after reconstitution - Proper storage conditions #### Warning Signs - Research chemical - limited quality standards - Not all cancers express membrane HDM-2 #### Bad Signs - Discoloration - Cloudy solution - Particulates visible ## Research & References ### Key References 1. 2010 #### Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes PNAS PNC-27 binds membrane-bound HDM-2, inducing pore formation and cancer cell necrosis while sparing normal cells. 2. 2024 #### Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes PubMed PNC-27 also enters cancer cells and disrupts mitochondrial membranes. 3. 2014 #### PNC-27 Induces Tumor Cell Necrosis of Leukemia Cells Annals of Clinical & Laboratory Science PNC-27 induces necrosis of K-562 leukemia cells lacking p53 through p53-independent pathway. 4. 2022 #### PNC-27, a Chimeric p53-Penetratin Peptide PubMed PNC-27 binds HDM-2 in p53 peptide-like structure, induces selective membrane-pore formation leading to cancer cell lysis. [Search PubMed for PNC-27](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22PNC-27%22%20OR%20%22PNC27%22%20OR%20%22p53-Penetratin%20Chimeric%20Peptide%22%29) Research Library ## PNC-27 research & guides Plain-English guides and study summaries from published literature. [View all 2](https://peptidesupermarket.co.za/research/peptide/pnc-27) ![PNC-27 Peptide Guide: Mechanism, Research Status and Safety Context](https://peptidesupermarket.co.za/storage/1616/conversions/PNC27-PepsupSA-image-thumbnail.jpg) Guides 6 min ### PNC-27 Peptide Guide: Mechanism, Research Status and Safety Context PNC-27 is an experimental peptide studied for cancer-cell selectivity through HDM-2 binding and membrane pore formation. It remains a research compound, with no approved human protocol. Read article [PNC-27 Peptide Guide: Mechanism, Research Status and Safety Context](https://peptidesupermarket.co.za/research/pnc-27-peptide-guide-mechanism-research-status-and-safety-context) ![PNC-27 Guide: What the Experimental Cancer Peptide Research Actually Shows](https://peptidesupermarket.co.za/storage/1462/conversions/PNC27-PepsupSA-image-thumbnail.jpg) Guides 7 min ### PNC-27 Guide: What the Experimental Cancer Peptide Research Actually Shows PNC-27 is an emerging experimental peptide studied for selective cancer-cell killing through HDM-2 binding. The evidence remains preclinical, and cancer treatment claims need strong caution. Read article [PNC-27 Guide: What the Experimental Cancer Peptide Research Actually Shows](https://peptidesupermarket.co.za/research/pnc-27-guide-what-the-experimental-cancer-peptide-research-actually-shows) --- *Add `.md` to any page URL on peptidesupermarket.co.za for its Markdown version. 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