--- title: "P21 Peptide SA - Compare Prices from 2 Suppliers - PeptideSupermarket®" description: "Compare P21 prices from 2 SA suppliers, from R570.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.za/peptide/p21" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › [Peptides](https://peptidesupermarket.co.za/compare-peptide-prices-za) › P21 Search # P21 Price Comparison Live prices from 2 SA suppliers, from R570.00, compared side by side so you never overpay. [Neuropeptides & sleep research](https://peptidesupermarket.co.za/compare-peptide-prices-za) Prices checked 53 minutes ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.za/disclosure). Best Price R570.00 Average R570.00 Highest R570.00 1 result 10mg Compare 1 price for P21. Cheapest: R570.00. Average: R570.00. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | [White Rabbit Labs](https://peptidesupermarket.co.za/suppliers/white-rabbit-labs) Best P21 10mg | R570.00 | R57.00/mg | Out of Stock | R120.00 | — | — | Visit | More ways to compare P21 Different views of the same live SA pricing, tuned for how you like to shop. [Best P21 Prices Best prices ranked](https://peptidesupermarket.co.za/best-p21-prices) [Cheapest P21 Prices Cheapest suppliers compared](https://peptidesupermarket.co.za/cheapest-p21-prices) [Where to Buy P21 Full buyer's guide](https://peptidesupermarket.co.za/where-to-buy-p21) [Buy P21 Online SA Cheap Today's hottest deals](https://peptidesupermarket.co.za/buy-p21-online-za-cheap) [P21 Price Comparison Live price dashboard](https://peptidesupermarket.co.za/p21-price-comparison) [P21 SA Supplier Verified SA supplier directory](https://peptidesupermarket.co.za/p21-za-supplier) [P21 For Sale Browse listings for sale](https://peptidesupermarket.co.za/p21-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). ## P21 Profile Emerging P021 | CNTF-Derived Neurogenic Peptide ### Overview P21 is a nootropic peptide derived from ciliary neurotrophic factor (CNTF) that enhances neurogenesis and cognitive function. It contains an adamantane moiety that enables blood-brain barrier penetration. Research shows it increases BDNF expression, inhibits LIF signaling to promote neurogenesis, and reduces tau and amyloid pathology in Alzheimer's disease models. Remarkably, P21 can boost neurogenesis in diseased brains above levels seen in healthy untreated brains. ### Mechanism of Action P21 operates through multiple pathways: it inhibits leukemia inhibitory factor (LIF) signaling, removing a key roadblock to neurogenesis and shifting the brain toward a more embryologic state favoring neuron growth. It increases brain-derived neurotrophic factor (BDNF) expression and activates the BDNF/TrkB/PI3-K/AKT/GSK3β pathway. This pathway modulation improves cognitive function and reduces tau and amyloid pathologies. ### Key Benefits - Potent promotion of neurogenesis in the dentate gyrus - Increased BDNF expression - Reduced tau protein pathology - Reduced amyloid-beta plaque formation - Improved cognitive function and memory - Restored synaptic deficits in cortex and hippocampus - Reduced mortality rate in AD models - Crosses blood-brain barrier effectively ### Quick Stats Typical Dose Research compound - dosing not established for humans Frequency Daily in animal research protocols Cycle Duration Not established - experimental peptide without human trials Storage Refrigerate at 2-8°C ## Molecular Information Molecular Weight ~1,100 Da Type CNTF-derived peptide Half-Life Over 3 hours (mouse plasma) ### Modifications Contains adamantane for BBB penetration ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Neurodegenerative Disease Cognitive Enhancement Neuroprotection ## Dosing Protocols ### injectable P21 has not yet been tested in human clinical trials. Research protocols in animal models use subcutaneous or intraperitoneal injection. The adamantane moiety enables blood-brain barrier penetration for CNS effects. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Research protocol | Variable by study | Daily | SubQ or IP | #### Key Tips - Adamantane enables BBB penetration - Promising preclinical results - Oral availability being researched Reconstitution Instructions ## Peptide Interactions #### Semax Compatible Different nootropic mechanisms; may complement each other. #### Dihexa Compatible Both promote neurogenesis through different pathways. #### BPC-157 Compatible No known negative interactions; different mechanisms. #### NA-Semax Amidate Compatible Different cognitive enhancement mechanisms. ## What to Expect Days-Weeks BDNF elevation begins Weeks Neurogenesis enhancement measurable Weeks-Months Cognitive improvements in research models Long-term Disease-modifying effects in AD models ## Side Effects & Safety #### Common Side Effects - Limited data - primarily preclinical research - Generally well-tolerated in animal studies #### Monitoring - Experimental peptide - medical supervision essential - No human clinical trials completed #### Stop Signs - Allergic reactions - Unusual neurological symptoms #### Contraindications - Not approved for human use - Pregnancy or breastfeeding - Unknown safety profile in humans ## Quality Checklist #### Good Signs - White lyophilized powder - Clear solution after reconstitution - High purity (>95%) - Intact vacuum seal #### Warning Signs - Research chemical - limited quality standards #### Bad Signs - Discoloration - Cloudy solution - Particulates visible ## Research & References ### Key References 1. 2018 #### P021 Treatment in 3xTg-AD Mice Journal of Alzheimer's Disease P021 markedly reduced tau pathology, attenuated Aβ, rescued episodic memory, and reduced mortality in AD mice. 2. 2019 #### P21 and BDNF/TrkB Pathway Neuropharmacology Disease-modifying effect via BDNF/TrkB/PI3-K/AKT/GSK3β pathway; rescued neurogenesis and cognition. 3. 2017 #### P21 in Cognitive Aging Neurobiology of Aging May reduce age-related cognitive decline by restoring BDNF expression and synaptic function. 4. 2020 #### P21 as Promising AD Drug Candidate Alzheimer's Research & Therapy Beneficial effects in preclinical studies make P21 highly promising for AD drug development. [Search PubMed for P21](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22P21%22%20OR%20%22P021%22%20OR%20%22CNTF%20peptide%20derivative%22%29) Research Library ## P21 research & guides Plain-English guides and study summaries from published literature. [View all 1](https://peptidesupermarket.co.za/research/peptide/p21) ![P21 Peptide Guide: Neuroplasticity, Memory and Brain Ageing Research](https://peptidesupermarket.co.za/storage/1404/conversions/PT21-Pepsup-image-thumbnail.jpg) Guides 8 min ### P21 Peptide Guide: Neuroplasticity, Memory and Brain Ageing Research P21 is an emerging CNTF-derived peptide studied for neurogenesis, BDNF signalling, memory and Alzheimer’s disease models. Human evidence remains limited, so claims need careful framing. 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