--- title: "Mots-C Peptide SA - Compare Prices from 38 Suppliers - PeptideSupermarket®" description: "Compare Mots-C prices from 38 SA suppliers, from R380.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.za/peptide/mots-c" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › [Peptides](https://peptidesupermarket.co.za/compare-peptide-prices-za) › Mots-C Search # Mots-C Price Comparison Live prices from 38 SA suppliers, from R380.00, compared side by side so you never overpay. [Skin & cellular longevity research](https://peptidesupermarket.co.za/compare-peptide-prices-za) Prices checked 53 minutes ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.za/disclosure). Best Price R400.00 Average R859.09 Highest R2,961.00 You Could Save 86% 32 results 10mg Compare 32 prices for Mots-C. Cheapest: R400.00. Average: R859.09. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | [Striata Labs](https://peptidesupermarket.co.za/suppliers/striata-labs) Best Mots-C 10mg | R400.00 | R40.00/mg | In Stock | R150.00 | Lab Tested | — | Visit | | | [White Rabbit Labs](https://peptidesupermarket.co.za/suppliers/white-rabbit-labs) Mots-C 10mg | R520.00 | R52.00/mg | In Stock | R120.00 | — | — | Visit | | | [TrueForm](https://peptidesupermarket.co.za/suppliers/trueform) Mots-C 10mg | R550.00 | R55.00/mg | In Stock | Free over R4,000 | — | — | Visit | | | [JP Research](https://peptidesupermarket.co.za/suppliers/jp-research) Mots-C | R599.00 | R59.90/mg | In Stock | Free | Lab Tested | — | Visit | | | [Neurovia](https://peptidesupermarket.co.za/suppliers/neurovia) Mots-C 10mg | R600.00 | R60.00/mg | In Stock | R250.00 | Lab Tested | — | Visit | | | [Peptera](https://peptidesupermarket.co.za/suppliers/peptera) Mots-C | R650.00 R617.50 | R61.75/mg | In Stock | R185.00 | — | PEPTIDESUPERMARKET05 5% off applied | Visit | | | [Peptide Warehouse](https://peptidesupermarket.co.za/suppliers/peptide-warehouse) Mots-C 10mg | R625.00 | R62.50/mg | In Stock | R95.00 | Lab Tested | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) Mots-C 10mg | R630.00 | R63.00/mg | In Stock | R170.00 | — | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) Mots-C 10mg | R650.00 | R65.00/mg | In Stock | R170.00 | — | — | Visit | | | [Ignite Muscle](https://peptidesupermarket.co.za/suppliers/ignite-muscle) Mots-C 10mg | R650.00 | R65.00/mg | In Stock | R250.00 | — | — | Unavailable | | | [Ignite Muscle](https://peptidesupermarket.co.za/suppliers/ignite-muscle) Mots-C 10mg | R700.00 | R70.00/mg | In Stock | R250.00 | — | — | Unavailable | | | [Limitless Peptides](https://peptidesupermarket.co.za/suppliers/limitless-peptides) Mots-C | R700.00 | R70.00/mg | In Stock | R90.00 | Lab Tested | — | Visit | | | [Pure Performance Labs](https://peptidesupermarket.co.za/suppliers/pure-performance-labs) Mots-C 10mg | R734.85 | R73.49/mg | In Stock | R250.00 | Lab Tested | — | Visit | | | [Peptide Labs](https://peptidesupermarket.co.za/suppliers/peptide-labs) Mots-C 10mg | R750.00 | R75.00/mg | In Stock | R170.00 | — | — | Visit | | | [Pure Peptides SA](https://peptidesupermarket.co.za/suppliers/pure-peptides-sa) Mots-C 10mg | R750.00 | R75.00/mg | In Stock | R200.00 | — | — | Visit | | | [SA Peptides](https://peptidesupermarket.co.za/suppliers/sa-peptides) Mots-C 10mg | R775.00 | R77.50/mg | In Stock | R140.00 | — | — | Visit | | | [Buy Peptides](https://peptidesupermarket.co.za/suppliers/buy-peptides) Mots-C 10mg | R775.00 | R77.50/mg | In Stock | R250.00 | — | — | Visit | | | [Molon Labs](https://peptidesupermarket.co.za/suppliers/molon-labs) Mots-C | R800.00 | R80.00/mg | In Stock | Free | Lab Tested | — | Visit | | | [Gander Peptides](https://peptidesupermarket.co.za/suppliers/gander-peptiodes) Mots-C 10mg | R802.00 | R80.20/mg | In Stock | R159.00 | Lab Tested | — | Visit | | | [ReGen-X](https://peptidesupermarket.co.za/suppliers/regen-x) Mots-C 10mg | R850.00 | R85.00/mg | In Stock | Free over R1,200 | — | — | Visit | | | [Kynex Bioscience](https://peptidesupermarket.co.za/suppliers/kynex-bioscience) Mots-C 10mg | R870.00 | R87.00/mg | In Stock | Free over R2,200 | Lab Tested | — | Visit | | | [Buy Peptides](https://peptidesupermarket.co.za/suppliers/buy-peptides) Mots-C 10mg | R875.00 | R87.50/mg | In Stock | R250.00 | — | — | Visit | | | [Reschem](https://peptidesupermarket.co.za/suppliers/reschem) Mots-C Pen | R879.00 | R87.90/mg | Out of Stock | Free over R600 | Lab Tested | — | Visit | | | [Grow Nova](https://peptidesupermarket.co.za/suppliers/grow-nova) Mots-C 10mg | R950.00 | R95.00/mg | In Stock | R170.00 | — | — | Visit | | | [Blaque Sigma](https://peptidesupermarket.co.za/suppliers/blue-sigma) Mots-C 10mg | R950.00 | R95.00/mg | In Stock | R150.00 | Lab Tested | — | Visit | Showing 25 of 32 listings Show more suppliers Loading More ways to compare Mots-C Different views of the same live SA pricing, tuned for how you like to shop. [Best Mots-C Prices Best prices ranked](https://peptidesupermarket.co.za/best-mots-c-prices) [Cheapest Mots-C Prices Cheapest suppliers compared](https://peptidesupermarket.co.za/cheapest-mots-c-prices) [Where to Buy Mots-C Full buyer's guide](https://peptidesupermarket.co.za/where-to-buy-mots-c) [Buy Mots-C Online SA Cheap Today's hottest deals](https://peptidesupermarket.co.za/buy-mots-c-online-za-cheap) [Mots-C Price Comparison Live price dashboard](https://peptidesupermarket.co.za/mots-c-price-comparison) [Mots-C SA Supplier Verified SA supplier directory](https://peptidesupermarket.co.za/mots-c-za-supplier) [Mots-C For Sale Browse listings for sale](https://peptidesupermarket.co.za/mots-c-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). ## Mots-C Profile Well Studied Mitochondrial-Derived Peptide | Metabolic Regulator ### Overview MOTS-c is a mitochondrial-derived peptide that operates as a mitohormone through the Folate-AICAR-AMPK pathway. Under metabolic stress, it translocates to the nucleus to bind stress-response transcription factors (NRF2, ATF1/ATF7), regulating genes involved in metabolism and cellular adaptation. ### Mechanism of Action Inhibits the folate cycle leading to AMPK activation. Under metabolic stress, translocates to nucleus to bind stress-response transcription factors, regulating genes involved in metabolism, insulin sensitivity, and cellular adaptation. ### Key Benefits - Enhanced insulin sensitivity (~30% improvement) - Improved glucose metabolism and tolerance - AMPK pathway activation - Mitochondrial function optimization - Exercise performance enhancement (12-15% improvement) - Potential lifespan extension (6.4% median increase in mice) ### Quick Stats Typical Dose Start 5mg daily, increase to 10-15mg based on goals Frequency Daily for metabolic support, or 3x weekly for anti-aging Cycle Duration 4-12 weeks depending on goals Storage Refrigerate reconstituted solution at 2-8°C, use within 14 days ## Molecular Information Molecular Weight 2,174.6 Da Length 16 amino acids Type Mitochondrial-derived peptide (MDP) Half-Life ~30 minutes ### Amino Acid Sequence One-letter: `MRWQEMGYIFYPRKLR` Met 1 Methionine Position 1 Arg 2 Arginine Position 2 Trp 3 Tryptophan Position 3 Gln 4 Glutamine Position 4 Glu 5 Glutamic Acid Position 5 Met 6 Methionine Position 6 Gly 7 Glycine Position 7 Tyr 8 Tyrosine Position 8 Ile 9 Isoleucine Position 9 Phe 10 Phenylalanine Position 10 Tyr 11 Tyrosine Position 11 Pro 12 Proline Position 12 Arg 13 Arginine Position 13 Lys 14 Lysine Position 14 Leu 15 Leucine Position 15 Arg 16 Arginine Position 16 N-terminus C-terminus Hydrophobic Polar Positive (+) Negative (-) Modified ### Modifications Encoded by mitochondrial DNA (MT-RNR1 gene) within 12S rRNA ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Metabolic Anti-Aging Exercise Performance ## Dosing Protocols ### injectable Subcutaneous injection is the primary route. Optimal administration is morning before exercise. AMPK activation occurs within 30 minutes. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Metabolic health | 5-10mg | Once daily | SubQ | | Anti-aging protocol | 15mg | 3x weekly | SubQ | | Exercise performance | 10-15mg | Pre-workout | SubQ | | Conservative start | 5mg | Once daily | SubQ | #### Key Tips - Morning before exercise is optimal timing - AMPK activation within 30 minutes - Use within 14 days of reconstitution Reconstitution Instructions ## Peptide Interactions #### Metformin Monitor Both activate AMPK; monitor for additive hypoglycemic effects. #### NAD+ Precursors Synergistic Complementary mitochondrial enhancement through different pathways. #### Growth Hormone Peptides Compatible Different mechanisms allow safe combination. #### Berberine Monitor Both are AMPK activators; monitor for additive effects. #### Resveratrol Synergistic Complementary SIRT1/AMPK activation pathways. #### Diabetes Medications Monitor May require dose adjustments to prevent hypoglycemia. ## What to Expect Week 1-2 AMPK pathway activation; initial glucose tolerance improvements Week 2-4 Enhanced exercise capacity; improved insulin sensitivity Week 4-8 Sustained metabolic benefits; potential body composition changes Week 8-12 Maximum mitochondrial function enhancement; metabolic flexibility ## Side Effects & Safety #### Common Side Effects - Generally well-tolerated in animal studies with minimal side effects - Mild injection site reactions (redness, swelling) #### Monitoring - Blood glucose if using diabetes medications - Monitor for hypoglycemia symptoms - Start conservatively (5-10mg) - Appropriate medical supervision recommended #### Stop Signs - Severe allergic reactions or anaphylaxis - Recurrent hypoglycemia (<50 mg/dL) - Persistent severe injection site reactions - Unexplained weight loss >10% of baseline #### Contraindications - Pregnancy or breastfeeding - WADA prohibited substance (banned for athletic competition) - Limited long-term human safety data ## Quality Checklist #### Good Signs - White to off-white powder with uniform appearance indicating proper storage - Clear, colorless solution without particles after reconstitution - Sequence verification (MRWQEMGYIFYPRKLR) with CoA >95% purity by RP-HPLC #### Warning Signs - Limited human clinical data - start conservatively - WADA banned substance - not for competitive athletes #### Bad Signs - Discolored powder or solution - Cloudy solution after reconstitution - No certificate of analysis available ## Research & References ### Latest Research 2025 #### Age-Related Macular Degeneration Study Ophthalmology Research Dose-dependent protective effects on retinal cells in AMD models. ### Key References 1. 2015 #### Obesity and Insulin Sensitivity Study - Lee et al. Cell Metabolism Prevented obesity, improved insulin sensitivity by ~30% in high-fat diet mice. 2. 2021 #### Physical Performance Across Age Groups - Reynolds et al. Nature Communications Enhanced physical performance across age groups; exercise induced 11.9-fold increase in skeletal muscle MOTS-c. 3. 2018 #### Nuclear Translocation Study - Kim et al. Cell Metabolism Nuclear translocation within 30 minutes under metabolic stress. 4. 2022 #### Running Performance Study - Hyatt et al. Physiological Reports Single dose improved running time 12%, distance 15%. 5. 2022 #### Gestational Diabetes Study - Yin et al. Pharmacological Research Alleviated hyperglycemia in gestational diabetes model. [Search PubMed for Mots-C](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22Mots-C%22%20OR%20%22Mitochondrial%20Open%20Reading%20Frame%20of%20the%2012S%20rRNA-c%20%28C%29%22%20OR%20%22Mitochondrial%20Open%20Reading%20Frame%20of%20the%2012S%20rRNA-c%22%29) Research Library ## Mots-C research & guides Plain-English guides and study summaries from published literature. [View all 4](https://peptidesupermarket.co.za/research/peptide/mots-c) ![MOTS-c peptide guide: mitochondrial signalling, metabolism and exercise research](https://peptidesupermarket.co.za/storage/1621/conversions/PepSupSA-Mots-C-thumbnail.jpg) Guides 8 min ### MOTS-c peptide guide: mitochondrial signalling, metabolism and exercise research MOTS-c is a mitochondrial-derived peptide studied for metabolic signalling, insulin sensitivity, mitochondrial function and exercise performance. Here is what current research-focused discussion supports, and where caution is needed. Read article [MOTS-c peptide guide: mitochondrial signalling, metabolism and exercise research](https://peptidesupermarket.co.za/research/mots-c-peptide-guide-mitochondrial-signalling-metabolism-and-exercise-research) ![MOTS-c fatigue: why this metabolic peptide may feel confusing](https://peptidesupermarket.co.za/storage/1388/conversions/PepSup-Mots-C-thumbnail.jpg) Guides 8 min ### MOTS-c fatigue: why this metabolic peptide may feel confusing MOTS-c is often discussed in relation to energy, metabolism and mitochondrial signalling. Early fatigue should be interpreted cautiously, not assumed to be proof that it is working. Read article [MOTS-c fatigue: why this metabolic peptide may feel confusing](https://peptidesupermarket.co.za/research/mots-c-fatigue-why-this-metabolic-peptide-may-feel-confusing) ![MOTS-c South Africa: Research Guide to Metabolism and Energy](https://peptidesupermarket.co.za/storage/1361/conversions/PepSup-Mots-C-thumbnail.jpg) Guides 8 min ### MOTS-c South Africa: Research Guide to Metabolism and Energy MOTS-c is a mitochondrial-derived peptide studied for metabolic adaptation, insulin sensitivity, exercise performance and ageing. Here is what the research says, and what it does not yet prove. Read article [MOTS-c South Africa: Research Guide to Metabolism and Energy](https://peptidesupermarket.co.za/research/mots-c-south-africa-research-guide-to-metabolism-and-energy) ![MOTS-c and Fatigue: Why an Energy-Related Peptide May Not Feel Energising](https://peptidesupermarket.co.za/storage/1345/conversions/PepSup-Mots-C-thumbnail.jpg) Guides 8 min ### MOTS-c and Fatigue: Why an Energy-Related Peptide May Not Feel Energising MOTS-c is studied for metabolic signalling and mitochondrial function, but that does not mean it should feel like a stimulant. Fatigue reports need careful context. Read article [MOTS-c and Fatigue: Why an Energy-Related Peptide May Not Feel Energising](https://peptidesupermarket.co.za/research/mots-c-and-fatigue-why-an-energy-related-peptide-may-not-feel-energising) --- *Add `.md` to any page URL on peptidesupermarket.co.za for its Markdown version. 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