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# Crystagen Price Comparison

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## Crystagen Profile

Moderate Research

EDP Tripeptide | Thymus Immune Bioregulator

### Overview

Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it enhances immune function by stimulating normal lymphocyte proliferation while inhibiting tumor cell growth. Research shows effectiveness in normalizing immunity in 82% of elderly patients (vs 56% control) and reducing respiratory infections in athletes by doubling HSP gene expression.

### Mechanism of Action

Crystagen works through epigenetic regulation by influencing gene expression and protein synthesis in immune cells. It regulates the synthesis of heat-shock proteins, cytokines, and affects cell differentiation, proliferation, and apoptosis. The EDP peptide enhances spontaneous proliferative activity of normal lymphocytes while inhibiting proliferation of tumor cells (K-562 erythromyelosis). It activates B-cell immune system and thymic epithelial cells (VTEC2.H/S).

### Key Benefits

- Normalizes immune function in 82% of patients
- Stimulates normal lymphocyte proliferation
- Inhibits tumor cell growth (antitumor activity)
- Doubles HSP gene expression (stress resistance)
- Reduces respiratory viral infections
- Activates B-cell immune system
- Normalizes IL-6 expression
- Effective after radiation/chemotherapy

### Quick Stats

Typical Dose

10-20 mg daily

Frequency

Once daily for 10-20 consecutive days

Cycle Duration

10-20 days per cycle

Storage

Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated

## Molecular Information

Molecular Weight

359 Da

Length

3 amino acids

Type

Tripeptide bioregulator

Half-Life

Minutes (short peptide); effects persist via epigenetic changes

### Amino Acid Sequence

One-letter: `EDP`

Glu

1

Glutamic Acid

Position 1

Asp

2

Aspartic Acid

Position 2

Pro

3

Proline

Position 3

N-terminus C-terminus

Hydrophobic

Polar

Positive (+)

Negative (-)

Modified

## Research Indications

The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research.

Immune Support Stress Resistance Anti-Tumor

## Dosing Protocols

### oral

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.

| Goal | Dose | Frequency | Route |
| --- | --- | --- | --- |
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
| Athletic support | 10-20 mg | Daily during training cycles | Oral capsules |

#### Key Tips

- Convenient oral administration
- Short peptide allows GI absorption
- Room temperature storage for capsules

### injectable

Injectable form available for direct administration.

| Goal | Dose | Frequency | Route |
| --- | --- | --- | --- |
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |

#### Key Tips

- Direct absorption
- Precise dosing

Reconstitution Instructions

## Peptide Interactions

#### Vilon

Synergistic

Both have immunoprotecting properties; different mechanisms complement each other.

#### Thymalin

Synergistic

Crystagen (EDP) is derived from thymalin; complementary immune effects.

#### Epitalon

Synergistic

Often combined in comprehensive anti-aging Khavinson protocols.

#### Thymogen

Compatible

Related immune peptides; can be used together.

## What to Expect

During cycle

Immune activation and gene expression modulation begins

Post-cycle

Effects persist due to epigenetic changes

Weeks

Measurable immune function improvements

Long-term

Cumulative benefits with periodic cycles

## Side Effects & Safety

#### Common Side Effects

- Generally well-tolerated
- Minimal side effects reported

#### Stop Signs

- Allergic reactions
- Unusual immune symptoms

#### Contraindications

- Active autoimmune flares (consult physician)
- Known hypersensitivity
- Pregnancy or breastfeeding

## Quality Checklist

#### Good Signs

- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling

#### Warning Signs

- Unknown source or purity

#### Bad Signs

- Discoloration
- Unusual odor
- Damaged packaging

## Research & References

### Key References

1. 2021

#### The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity

PMC/NCBI

EDP (crystagen) identified in thymalin; regulates gene expression, HSP synthesis, cytokines, and cell differentiation.
2. 2018

#### Crystagen in Elderly Patients with Impaired Immunity

Advances in Gerontology

Crystagen normalized immunogram in 82% of patients vs 56% in control group.
3. 2019

#### Peptide Bioregulators in Athletes

Bulletin of Experimental Biology and Medicine

Crystagen doubled HSP gene expression, normalized IL-6, and reduced respiratory infections in athletes.
4. 2017

#### EDP Peptide Effects on Lymphocyte Proliferation

Cell Technologies in Biology and Medicine

EDP enhances normal lymphocyte proliferation while inhibiting K-562 tumor cell proliferation.

[Search PubMed for Crystagen](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22Crystagen%22%20OR%20%22EDP%22%20OR%20%22Glu-Asp-Pro%22%20OR%20%22Thymus%20Tripeptide%22%20OR%20%22Immune%20Bioregulator%22%29)

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