--- title: "Adipotide Peptide SA - Compare Prices from 3 Suppliers - PeptideSupermarket®" description: "Compare Adipotide prices from 3 SA suppliers, from R400.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.za/peptide/adipotide" site: "PeptideSupermarket®" country: "South Africa" --- [Home](https://peptidesupermarket.co.za) › [Peptides](https://peptidesupermarket.co.za/compare-peptide-prices-za) › Adipotide Search # Adipotide Price Comparison Live prices from 3 SA suppliers, from R400.00, compared side by side so you never overpay. [GLP-1 & metabolic research](https://peptidesupermarket.co.za/compare-peptide-prices-za) Prices checked 1 hour ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.za/disclosure). Best Price R699.00 Average R724.50 Highest R750.00 You Could Save 7% 2 results 5mg Compare 2 prices for Adipotide. Cheapest: R699.00. Average: R724.50. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | [JP Research](https://peptidesupermarket.co.za/suppliers/jp-research) Best Adipotide | R699.00 | R139.80/mg | In Stock | Free | Lab Tested | — | Visit | | | [Buy Peptides](https://peptidesupermarket.co.za/suppliers/buy-peptides) Adipotide 5mg | R750.00 | R150.00/mg | Out of Stock | R250.00 | — | — | Visit | More ways to compare Adipotide Different views of the same live SA pricing, tuned for how you like to shop. [Best Adipotide Prices Best prices ranked](https://peptidesupermarket.co.za/best-adipotide-prices) [Cheapest Adipotide Prices Cheapest suppliers compared](https://peptidesupermarket.co.za/cheapest-adipotide-prices) [Where to Buy Adipotide Full buyer's guide](https://peptidesupermarket.co.za/where-to-buy-adipotide) [Buy Adipotide Online SA Cheap Today's hottest deals](https://peptidesupermarket.co.za/buy-adipotide-online-za-cheap) [Adipotide Price Comparison Live price dashboard](https://peptidesupermarket.co.za/adipotide-price-comparison) [Adipotide SA Supplier Verified SA supplier directory](https://peptidesupermarket.co.za/adipotide-za-supplier) [Adipotide For Sale Browse listings for sale](https://peptidesupermarket.co.za/adipotide-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.za/disclosure). ## Adipotide Profile Emerging Prohibitin-Targeting Peptidomimetic | Experimental Anti-Obesity ### Overview Chimeric adipose-vasculature-targeted peptidomimetic targeting prohibitin/annexin A2 on white adipose tissue endothelium, delivering pro-apoptotic D-(KLAKLAK)2 motif. In obese primates it produced rapid fat loss with improved insulin resistance, yet development halted after Phase 1 due to kidney safety signals. ### Mechanism of Action CKGGRAKDC ligand homes to prohibitin/annexin A2 on white-fat endothelium; linked D-(KLAKLAK)2 disrupts mitochondrial membranes post-internalization, triggering localized endothelial apoptosis and adipocyte loss. ### Key Benefits - Rapid fat-mass reduction via selective white adipose tissue vascular targeting - Improved insulin sensitivity following adipose reduction - Non-CNS peripheral mechanism distinct from appetite suppressants ### Quick Stats Typical Dose 0.43 mg/kg Frequency Once daily Cycle Duration 28 days Storage Lyophilized: -20°C freezer. Reconstituted: 2-8°C refrigerated ## Molecular Information Molecular Weight N/A Length N/A Type Chimeric peptidomimetic Half-Life Not established ### Amino Acid Sequence `CKGGRAKDC-GG-D(KLAKLAK)2` ### Modifications D-amino acid motif for apoptosis induction ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Weight Loss Metabolic Appetite Control ## Dosing Protocols ### injectable Rapid fat-mass reduction in obese non-human primates with improved insulin sensitivity; direct white adipose tissue vascular targeting. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Primate Research Replication | 0.43 mg/kg | Once daily | SubQ | | Dose-Finding (Research) | 0.10-0.75 mg/kg | Once daily (escalating tiers) | SubQ | #### Key Tips - Rapid fat-mass reduction - Improved insulin sensitivity - Direct tissue targeting Reconstitution Instructions ## Peptide Interactions #### Semaglutide Monitor Potential additive dehydration/GI effects; monitor renal function. #### Tirzepatide Monitor Overlapping weight-loss effects; monitor kidney function, volume status, electrolytes. #### Cagrilintide Monitor No clinical data on co-administration; mechanisms differ. #### AOD-9604 Monitor No published data on combined use or pharmacodynamic interaction. #### BPC-157 Compatible No known direct interaction; distinct mechanisms and targets. #### CJC-1295/Ipamorelin Monitor Metabolic effects may confound body-composition endpoints. #### Melanotan II Monitor Theoretical vascular/pressor effects; stagger dosing, monitor BP and hydration. #### Nephrotoxic Drugs Avoid Adipotide shows dose-dependent proximal tubule injury; avoid additional renal insults. ## What to Expect Week 1-2 Early reduction in abdominal circumference Week 2-4 Progressive weight/fat-mass decline Post-Discontinuation Partial rebound possible; lab signals include mild creatinine rise and electrolyte shifts ## Side Effects & Safety #### Common Side Effects - Mild creatinine elevation - Electrolyte shifts - Dose-dependent proximal tubule changes (reversible in primates) #### Monitoring - Serum creatinine weekly - Blood urea nitrogen (BUN) weekly - Urinalysis weekly - Electrolytes weekly #### Stop Signs - Sustained creatinine elevation or oliguria - Progressive electrolyte abnormalities - Severe injection-site reactions or systemic symptoms - Unexpected toxicity #### Contraindications - Pregnancy/lactation (not studied) - Dehydration - Concurrent nephrotoxic medications ## Quality Checklist #### Good Signs - Intact lyophilized cake - white, uniform indicates proper lyophilization - Clear solution - fully dissolved, particle-free after reconstitution #### Warning Signs - Minor clumping may form from shipping; should dissolve with gentle swirl #### Bad Signs - Collapsed/moist cake suggests temperature excursion; do not use without QC - Cloudiness/precipitate indicates degradation or contamination—discard ## Research & References ### Key References 1. 2011 #### A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys Rhesus macaques at 0.43 mg/kg SC daily for 28 days showed 7.4-14.7% weight loss; insulin resistance improved; mild, dose-dependent, reversible proximal tubule changes. 2. 2004 #### Reversal of obesity by targeted ablation of adipose tissue Mice with diet-induced obesity showed ~30% weight reduction; adipose vascular apoptosis; metabolic normalization. 3. 2016 #### Prohibitin/Annexin A2 Interaction Regulates Fatty-Acid Transport Mechanistic validation of prohibitin/ANXA2 axis in adipose tissue, core to TP01 targeting. 4. 2025 #### Mixed-Chirality Prohibitin Peptide: D-(RLARLAR)2 Enhances Stability Next-generation prohibitin constructs improve serum stability and efficacy vs. first-generation TP01. 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